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Moderna says COVID-19 vaccine protection wanes, makes case for booster

Reuters2021-09-16

CHICAGO, Sept 15 (Reuters) - New data from Moderna Inc's large COVID-19 vaccine trial shows that the protection it offers wanes over time, supporting the case for booster doses, the company said in a news release on Wednesday.

"This is only one estimate, but we do believe this means as you look toward the fall and winter, at minimum we expect the estimated impact of waning immunity would be 600,000 additional cases of COVID-19," Moderna President Stephen Hoge said on a conference call with investors.

Hoge did not project how many of the cases would be severe, but said some would require hospitalization.

The data stands in stark contrast with data from several recent studies that suggested Moderna's vaccine protection lasts longer than a similar shot from Pfizer Inc and German partner BioNTech SE .

Experts said the difference is likely due to Moderna's higher dose of messenger RNA (mRNA) and the slightly longer interval between the first and second shots.

Both vaccines proved to be exceedingly effective at preventing illness in their large Phase III studies.

Wednesday's analysis, however, showed higher rates of infection among people vaccinated roughly 13 months ago compared with those vaccinated roughly eight months ago. The study period was from July-August, when Delta was the predominant strain. It has yet to undergo peer review.

Moderna on Sept. 1 submitted its application to the U.S. Food and Drug Administration seeking authorization for a booster shot.

Hoge said data from its booster studies shows the vaccine could increase neutralizing antibodies to levels even higher than were seen after the second dose.

"We believe this will reduce COVID-19 cases," he said. "We also believe that a third dose of mRNA-1273 has a chance of significantly extending immunity throughout much of next year as we attempt to end the pandemic."

Briefing documents from the FDA's analysis of Pfizer's booster application, released earlier on Wednesday, suggest that a key issue the agency will consider is whether vaccine protection is waning

In its analysis, Moderna compared the vaccine's performance in more than 14,000 volunteers vaccinated between July and October of 2020 with some 11,000 volunteers originally in the placebo group who were offered the shot between December 2020 and March 2022 following its U.S. emergency use authorization.

In the two-month period from July-August, researchers identified 88 COVID-19 cases among those who got the two shots more recently, compared with 162 cases among those vaccinated last year. Overall, only 19 cases were considered severe, a key benchmark in assessing waning protection.

Moderna said there was a trend toward a lower rate of severe cases among the more recently vaccinated, although the finding was not statistically significant.

Data from a separate study presented on Wednesday conducted with Kaiser Permanente Southern California health system, meanwhile, shows that Moderna's vaccine continued to perform well against the Delta variant.

Researchers compared data on more than 352,000 people who got two doses of the Moderna vaccine with the same number of unvaccinated individuals and found the Moderna vaccine was 87% effective at preventing a COVID-19 diagnosis, and 96% effective at preventing hospitalization.

Hoge said the vaccine's initial performance is strong, but argued that protection shouldn't be allowed to wane.

"The first six months are great, but you can't count on that being stable out to a year and beyond," he said.

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  • SSVC
    ·2021-09-16
    Mm..appreciate your comments and response Thanks 
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  • BensonTong
    ·2021-09-16
    Gd
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  • Someonelse
    ·2021-09-16
    Share price up for this again
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    • YiiYii
      [财迷]
      2021-09-16
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  • Andrew210782
    ·2021-09-16
    Like
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  • Rickyt089
    ·2021-09-16
    Like pls 
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  • Blading23
    ·2021-09-16
    Read
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    • Blading23
      comment
      2021-09-16
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  • MN27
    ·2021-09-16
    Like pls
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    • HillaryV
      Good Money making
      2021-09-16
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  • SP1980
    ·2021-09-16
    Gogogo
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  • AppleMango
    ·2021-09-16
    Emphasis on booster to earn much more
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    • ngckkk
      yes!!
      2021-09-16
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    • TkLm
      Generating demand for more sales
      2021-09-16
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    • invest4value
      Probably the case
      2021-09-16
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    查看更多 1 条评论
  • adelee
    ·2021-09-16
    Haiz
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  • dho
    ·2021-09-16
    It's not a vaccine! 
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  • blkgoat00
    ·2021-09-16
    [得意] [得意] [财迷] [财迷] 
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  • NRN
    ·2021-09-16
    🚀
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  • Shivani
    ·2021-09-16
    At which point do the boosters stop? 
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  • GohKS
    ·2021-09-16
    Latest. Please like and comment. Thank you.
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    • Shivani
      Done pls do too
      2021-09-16
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  • Kirt
    ·2021-09-16
    like please
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    • GohKS
      Latest. Please like and comment. Thank you.
      2021-09-16
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  • IZLIN
    ·2021-09-16
    @Sagi08@Meow17@simplydkamboost boost boost!
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    • Kirt
      mhm
      2021-09-16
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  • 14561b30
    ·2021-09-16
    Booster
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