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韭菜PIKA
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IP属地:湖北
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韭菜PIKA
2022-01-05
总共买了多少
抱歉,原内容已删除
韭菜PIKA
2021-11-27
哈哈,前几天买了,套的死死地
@Eventide:
$维珍银河(SPCE)$
抄底了
韭菜PIKA
2021-04-07
稳步下行 [笑哭]
@Hoshihara:
$Sundial Growers Inc.(SNDL)$
就看你今晚会不会跌破1
韭菜PIKA
2020-12-13
这篇文章不错,转发给大家看
抱歉,原内容已删除
韭菜PIKA
2020-08-10
完了😱
@空军大队长:
$腾讯控股(00700)$
兄弟们抄底吗
韭菜PIKA
2020-04-27
韭菜PIKA
2020-04-26
港片《风云当当》上演
抱歉,原内容已删除
韭菜PIKA
2020-04-12
$达美航空(DAL)$
双方在博弈中。财政部要求给航空公司援助是贷款和换股,航空公司觉得我负债低经营利润率高,疫情结束困难就过去了,为什么要接受条件差的援助?!我又不是波音。再说,现在每天在烧钱,大头是员工工资,把员工辞退了,再加上贷款,我就可以度过困难。辞退员工工资还是你**发。川普急了,快点解决。援助定了,航空业定了,人心才稳了。看看双方能谈出什么样的援助方案,拭目以待。
抱歉,原内容已删除
韭菜PIKA
2020-04-11
$吉利德科学(GILD)$
在我看来,副作用大,死亡率降低一半,效果不明显。不过媒体和专业人士都说不错,那应该不错。如果股票涨说明市场认可。通过市场反映判断疗效[微笑]
抱歉,原内容已删除
韭菜PIKA
2020-04-05
小赌怡情,大赌伤身
抱歉,原内容已删除
韭菜PIKA
2020-03-11
$老虎证券(TIGR)$
特斯拉不常有,病猫常有。~来自接飞刀的人。
韭菜PIKA
2020-02-15
$吉利德科学(GILD)$
最新官方消息。集中主要药物的现状。貌似第二种 第三种效果都不错。第二批瑞德西韦药物已经到了武汉,应该是扩大临床试验范围。
韭菜PIKA
2016-04-29
美股这是怎么了?将会怎么样?
美股禁不起称赞的孩子,今年刚刚涨上来,最近$标普500指数ETF-SPDR(SPY)$ 有阴跌,为什么会这样?哪些原因导致的?大家对今年大盘有啥预测?为什么做这样的预测?请各抒己见,大家互相探讨一下。@Tony特别帅 @猫尔摩斯 @番茄君 @老虎证券 @IB关联户 @哆啦A梦
美股这是怎么了?将会怎么样?
韭菜PIKA
2016-01-14
迪士尼上海6月份要开园了
$迪士尼(DIS)$ 迪士尼马上要开园,利好消息,这么大盘子,上浮大吗?
迪士尼上海6月份要开园了
去老虎APP查看更多动态
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href=\"https://laohu8.com/U/422101323672\">@lily李</a>","text":"李国庆抢走公章的真相:意在离婚案平分股权,“想算计我一分钱,我都拼命”@小虎AV@Tony特别帅@许亚鑫@smallnew小牛@lily李","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":4,"commentSize":7,"repostSize":0,"link":"https://laohu8.com/post/925868133","isVote":1,"tweetType":3,"object":{"tweetId":"925868133","title":"李国庆抢走公章的真相:意在离婚案平分股权,“想算计我一分钱,我都拼命”","poster":"https://mmbiz.qpic.cn/mmbiz_png/KxXyoIgFFN8gQPYoJnJ3P0EIfuOAe1u6st3INWiccmuXwTdHdOibwYU4BuDT5khHN0LEH8KibRiaQrQshXLnC2Q8icw/640?wx_fmt=png","shareLink":"https://mp.weixin.qq.com/s/IE2233n7c4eBGl4Bg-RIaw"},"viewCount":2900,"authorTweetTopStatus":1,"verified":2,"comments":[{"author":{"id":"422101323672","authorId":"422101323672","name":"lily李","avatar":"https://static.tigerbbs.com/3e86f739a9b1416d39e71702733e6f2a","crmLevel":9,"crmLevelSwitch":0},"content":"也是自己创业后,发现很难再造出个同样的当当吧,才回头后悔[笑哭]","text":"也是自己创业后,发现很难再造出个同样的当当吧,才回头后悔[笑哭]","html":"也是自己创业后,发现很难再造出个同样的当当吧,才回头后悔[笑哭]"}],"imageCount":0,"langContent":"CN","totalScore":0},{"id":965307405,"gmtCreate":1583884634307,"gmtModify":1704351433885,"author":{"id":"51471756433604","authorId":"51471756433604","name":"韭菜PIKA","avatar":"https://static.laohu8.com/8790a4e6a56229acc72938aca19079cc","crmLevel":1,"crmLevelSwitch":0,"followedFlag":false},"themes":[],"htmlText":"<a href=\"https://laohu8.com/S/TIGR\">$老虎证券(TIGR)$</a>特斯拉不常有,病猫常有。~来自接飞刀的人。","listText":"<a href=\"https://laohu8.com/S/TIGR\">$老虎证券(TIGR)$</a>特斯拉不常有,病猫常有。~来自接飞刀的人。","text":"$老虎证券(TIGR)$特斯拉不常有,病猫常有。~来自接飞刀的人。","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":4,"commentSize":3,"repostSize":0,"link":"https://laohu8.com/post/965307405","isVote":1,"tweetType":1,"viewCount":2323,"authorTweetTopStatus":1,"verified":2,"comments":[{"author":{"id":"3516165326153666","authorId":"3516165326153666","name":"海天飞鸟","avatar":"https://static.tigerbbs.com/11525d1cb6ee5144cf68f0f61953987a","crmLevel":7,"crmLevelSwitch":0},"content":"原始股和、股权激励等等是赚的","text":"原始股和、股权激励等等是赚的","html":"原始股和、股权激励等等是赚的"}],"imageCount":0,"langContent":"CN","totalScore":0},{"id":917625722,"gmtCreate":1581759588166,"gmtModify":1704345164318,"author":{"id":"51471756433604","authorId":"51471756433604","name":"韭菜PIKA","avatar":"https://static.laohu8.com/8790a4e6a56229acc72938aca19079cc","crmLevel":1,"crmLevelSwitch":0,"followedFlag":false},"themes":[],"htmlText":"<a href=\"https://laohu8.com/S/GILD\">$吉利德科学(GILD)$</a> 最新官方消息。集中主要药物的现状。貌似第二种 第三种效果都不错。第二批瑞德西韦药物已经到了武汉,应该是扩大临床试验范围。","listText":"<a href=\"https://laohu8.com/S/GILD\">$吉利德科学(GILD)$</a> 最新官方消息。集中主要药物的现状。貌似第二种 第三种效果都不错。第二批瑞德西韦药物已经到了武汉,应该是扩大临床试验范围。","text":"$吉利德科学(GILD)$ 最新官方消息。集中主要药物的现状。貌似第二种 第三种效果都不错。第二批瑞德西韦药物已经到了武汉,应该是扩大临床试验范围。","images":[{"img":"https://static.tigerbbs.com/aa821fb10f3e6934cc5c9c7d0f247b1c","width":"1080","height":"2340"}],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":4,"repostSize":0,"link":"https://laohu8.com/post/917625722","isVote":1,"tweetType":1,"viewCount":3247,"authorTweetTopStatus":1,"verified":2,"comments":[{"author":{"id":"3506153078214938","authorId":"3506153078214938","name":"雪崩","avatar":"https://static.tigerbbs.com/51161e985eca732d547e36570f5522dc","crmLevel":1,"crmLevelSwitch":0},"content":"不需要质疑药效,就是得想想,股价还能拉不?","text":"不需要质疑药效,就是得想想,股价还能拉不?","html":"不需要质疑药效,就是得想想,股价还能拉不?"}],"imageCount":1,"langContent":"CN","totalScore":0},{"id":928884209,"gmtCreate":1586657928001,"gmtModify":1704361787403,"author":{"id":"51471756433604","authorId":"51471756433604","name":"韭菜PIKA","avatar":"https://static.laohu8.com/8790a4e6a56229acc72938aca19079cc","crmLevel":1,"crmLevelSwitch":0,"followedFlag":false},"themes":[],"htmlText":"<a href=\"https://laohu8.com/S/DAL\">$达美航空(DAL)$</a>双方在博弈中。财政部要求给航空公司援助是贷款和换股,航空公司觉得我负债低经营利润率高,疫情结束困难就过去了,为什么要接受条件差的援助?!我又不是波音。再说,现在每天在烧钱,大头是员工工资,把员工辞退了,再加上贷款,我就可以度过困难。辞退员工工资还是你**发。川普急了,快点解决。援助定了,航空业定了,人心才稳了。看看双方能谈出什么样的援助方案,拭目以待。","listText":"<a href=\"https://laohu8.com/S/DAL\">$达美航空(DAL)$</a>双方在博弈中。财政部要求给航空公司援助是贷款和换股,航空公司觉得我负债低经营利润率高,疫情结束困难就过去了,为什么要接受条件差的援助?!我又不是波音。再说,现在每天在烧钱,大头是员工工资,把员工辞退了,再加上贷款,我就可以度过困难。辞退员工工资还是你**发。川普急了,快点解决。援助定了,航空业定了,人心才稳了。看看双方能谈出什么样的援助方案,拭目以待。","text":"$达美航空(DAL)$双方在博弈中。财政部要求给航空公司援助是贷款和换股,航空公司觉得我负债低经营利润率高,疫情结束困难就过去了,为什么要接受条件差的援助?!我又不是波音。再说,现在每天在烧钱,大头是员工工资,把员工辞退了,再加上贷款,我就可以度过困难。辞退员工工资还是你**发。川普急了,快点解决。援助定了,航空业定了,人心才稳了。看看双方能谈出什么样的援助方案,拭目以待。","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":6,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/928884209","repostId":"2026931261","repostType":2,"repost":{"id":"2026931261","pubTimestamp":1586647260,"share":"https://www.laohu8.com/m/news/2026931261?lang=&edition=full","pubTime":"2020-04-12 07:21","market":"us","language":"en","title":"Airlines want U.S. Treasury to scrap proposal to make some grant money repayable","url":"https://stock-news.laohu8.com/highlight/detail?id=2026931261","media":"StreetInsider","summary":"By David Shepardson and Tracy Rucinski\nWASHINGTON/CHICAGO (Reuters) - Major U.S. airlines were urgin","content":"<html><body><div>\n<div>\n<div>\n<img src=\"https://www.streetinsider.com/images/news2/167/16733765/resize_LYNXNPEG3A0JN.jpg\"/>\n</div>\n</div>\n<p>By David Shepardson and Tracy Rucinski</p>\n<p>WASHINGTON/CHICAGO (Reuters) - Major U.S. airlines were urging Treasury officials and the federal government's outside advisers on Saturday to scrap or revise a proposal that would make part of the $25 billion earmarked by Congress to help keep workers on the payroll repayable in the form of low-cost loans.</p>\n<p>Treasury Secretary Steven Mnuchin told the airlines on Friday the government would require them to repay 30% of the grants in low-cost loans over 10 years -- with the first five years at 1% interest -- before the interest rate would rise. The government is also seeking warrants equal to 10% of the loan amount.</p>\n<p>U.S. airlines have idled more than 2,200 airplanes, a third of the fleet, canceled hundreds of thousands of flights and sought to shore up their balance sheets as travel demand has fallen by about 95% because of the coronavirus pandemic.</p>\n<p>Airlines, in calls with U.S. Treasury officials and the government's outside advisers, were making the case that Treasury should not require them to repay a big chunk of grants, in part because the $25 billion is not sufficient to cover the full amount of payroll costs submitted.</p>\n<p>Airlines for America, a trade group representing American Airlines Group Inc (NASDAQ: AAL), United Airlines (NASDAQ: UAL), Delta Air Lines (NYSE: DAL) Southwest Airlines Co (NYSE: LUV), JetBlue Airways Corp (NASDAQ: JBLU), Alaska Airlines (NYSE: ALK) and others, said Saturday it believes the $25 billion in payroll assistance was \"to be only in grants – which is considerably more effective for our employees – and not a combination of grants and loans.\"</p>\n<p>Under the terms laid out in the statute, companies receiving funds cannot lay off employees before Sept. 30 or change collective bargaining agreements. Mnuchin has authority to demand compensation for the grants but is not required to do so.</p>\n<p>Sara Nelson, president of the Association of Flight Attendants union, wrote on <a href=\"https://laohu8.com/S/TWTR\">Twitter</a> Saturday that if Treasury insists on airlines repaying $7 billion in grants, \"job cuts will happen now AND longer term cuts will come in October. This is absolutely stealing from the money Congress allocated directly to workers.\"</p>\n<p>Congress set aside another $25 billion in loans to passenger airlines, but no action on those is expected until Treasury makes decisions on the grants.</p>\n<p>Some airlines were seeking other changes in the terms including ensuring grant funds are paid as a lump sum rather than on a monthly basis.</p>\n<p>The Treasury said Friday Mnuchin will not require passenger air carriers that will receive $100 million in assistance or less to provide compensation.</p>\n<p>Reuters first reported the terms Mnuchin proposed to carriers.</p>\n<p>Treasury said Friday it is working with 12 larger passenger air carriers \"to secure appropriate financial instruments to compensate taxpayers.\"</p>\n<p>Airlines were told they could apply for the amount they paid in salaries and benefits in the second and third quarters of 2019. American Airlines, with the largest number of employees, had said it was seeking around $6 billion. </p>\n\n<p> (Reporting by David Shepardson and Tracy Rucinski; Editing by Leslie Adler)</p> </div></body></html>","source":"highlight_streetinsider","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Airlines want U.S. Treasury to scrap proposal to make some grant money repayable</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nAirlines want U.S. Treasury to scrap proposal to make some grant money repayable\n</h2>\n\n<h4 class=\"meta\">\n\n\n2020-04-12 07:21 GMT+8 <a href=https://www.streetinsider.com/dr/news.php?id=16733765><strong>StreetInsider</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>By David Shepardson and Tracy Rucinski\nWASHINGTON/CHICAGO (Reuters) - Major U.S. airlines were urging Treasury officials and the federal government's outside advisers on Saturday to scrap or revise a ...</p>\n\n<a href=\"https://www.streetinsider.com/dr/news.php?id=16733765\">Web Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"DAL":"达美航空","UAL":"联合大陆航空","AAL":"美国航空"},"source_url":"https://www.streetinsider.com/dr/news.php?id=16733765","is_english":true,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"2026931261","content_text":"By David Shepardson and Tracy Rucinski\nWASHINGTON/CHICAGO (Reuters) - Major U.S. airlines were urging Treasury officials and the federal government's outside advisers on Saturday to scrap or revise a proposal that would make part of the $25 billion earmarked by Congress to help keep workers on the payroll repayable in the form of low-cost loans.\nTreasury Secretary Steven Mnuchin told the airlines on Friday the government would require them to repay 30% of the grants in low-cost loans over 10 years -- with the first five years at 1% interest -- before the interest rate would rise. The government is also seeking warrants equal to 10% of the loan amount.\nU.S. airlines have idled more than 2,200 airplanes, a third of the fleet, canceled hundreds of thousands of flights and sought to shore up their balance sheets as travel demand has fallen by about 95% because of the coronavirus pandemic.\nAirlines, in calls with U.S. Treasury officials and the government's outside advisers, were making the case that Treasury should not require them to repay a big chunk of grants, in part because the $25 billion is not sufficient to cover the full amount of payroll costs submitted.\nAirlines for America, a trade group representing American Airlines Group Inc (NASDAQ: AAL), United Airlines (NASDAQ: UAL), Delta Air Lines (NYSE: DAL) Southwest Airlines Co (NYSE: LUV), JetBlue Airways Corp (NASDAQ: JBLU), Alaska Airlines (NYSE: ALK) and others, said Saturday it believes the $25 billion in payroll assistance was \"to be only in grants – which is considerably more effective for our employees – and not a combination of grants and loans.\"\nUnder the terms laid out in the statute, companies receiving funds cannot lay off employees before Sept. 30 or change collective bargaining agreements. Mnuchin has authority to demand compensation for the grants but is not required to do so.\nSara Nelson, president of the Association of Flight Attendants union, wrote on Twitter Saturday that if Treasury insists on airlines repaying $7 billion in grants, \"job cuts will happen now AND longer term cuts will come in October. This is absolutely stealing from the money Congress allocated directly to workers.\"\nCongress set aside another $25 billion in loans to passenger airlines, but no action on those is expected until Treasury makes decisions on the grants.\nSome airlines were seeking other changes in the terms including ensuring grant funds are paid as a lump sum rather than on a monthly basis.\nThe Treasury said Friday Mnuchin will not require passenger air carriers that will receive $100 million in assistance or less to provide compensation.\nReuters first reported the terms Mnuchin proposed to carriers.\nTreasury said Friday it is working with 12 larger passenger air carriers \"to secure appropriate financial instruments to compensate taxpayers.\"\nAirlines were told they could apply for the amount they paid in salaries and benefits in the second and third quarters of 2019. American Airlines, with the largest number of employees, had said it was seeking around $6 billion. \n (Reporting by David Shepardson and Tracy Rucinski; Editing by Leslie Adler)","news_type":1},"isVote":1,"tweetType":1,"viewCount":2978,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":928833082,"gmtCreate":1586603099846,"gmtModify":1704361754837,"author":{"id":"51471756433604","authorId":"51471756433604","name":"韭菜PIKA","avatar":"https://static.laohu8.com/8790a4e6a56229acc72938aca19079cc","crmLevel":1,"crmLevelSwitch":0,"followedFlag":false},"themes":[],"htmlText":"<a href=\"https://laohu8.com/S/GILD\">$吉利德科学(GILD)$</a>在我看来,副作用大,死亡率降低一半,效果不明显。不过媒体和专业人士都说不错,那应该不错。如果股票涨说明市场认可。通过市场反映判断疗效[微笑] ","listText":"<a href=\"https://laohu8.com/S/GILD\">$吉利德科学(GILD)$</a>在我看来,副作用大,死亡率降低一半,效果不明显。不过媒体和专业人士都说不错,那应该不错。如果股票涨说明市场认可。通过市场反映判断疗效[微笑] ","text":"$吉利德科学(GILD)$在我看来,副作用大,死亡率降低一半,效果不明显。不过媒体和专业人士都说不错,那应该不错。如果股票涨说明市场认可。通过市场反映判断疗效[微笑]","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":3,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/928833082","repostId":"2026266699","repostType":2,"repost":{"id":"2026266699","pubTimestamp":1586601691,"share":"https://www.laohu8.com/m/news/2026266699?lang=&edition=full","pubTime":"2020-04-11 18:41","market":"us","language":"zh","title":"鹅知道|瑞德西韦临床结果来了!效果超预期 改善重症患者作用明显","url":"https://stock-news.laohu8.com/highlight/detail?id=2026266699","media":"腾讯科技&知乎","summary":"(本文由知乎答主庄有猫撰文,腾讯科技整理,作者系知乎医学话题优秀回答者、日本北海道大学硕士、丁香医生签约作者)4月11日,吉利德在《新英格兰医学》杂志上发布了瑞德西韦(Remdesivir)治疗新冠肺","content":"<div>\n<p>(本文由知乎答主庄有猫撰文,腾讯科技整理,作者系知乎医学话题优秀回答者、日本北海道大学硕士、丁香医生签约作者)4月11日,吉利德在《新英格兰医学》杂志上发布了瑞德西韦(Remdesivir)治疗新冠肺炎(COVID-19)的首个临床研究结果。结果显示,在53名来自美国、欧洲、加拿大及日本的严重和危重新冠肺炎患者中,瑞德西韦给68%(36人)的患者带来临床改善。其中,57%(30/53)接受机械通气...</p>\n\n<a href=\"https://xw.qq.com/tech/20200411012101/TEC2020041101210100\">Web Link</a>\n\n</div>\n","source":"tencent_tech","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>鹅知道|瑞德西韦临床结果来了!效果超预期 改善重症患者作用明显</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ 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}\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\n鹅知道|瑞德西韦临床结果来了!效果超预期 改善重症患者作用明显\n</h2>\n\n<h4 class=\"meta\">\n\n\n2020-04-11 18:41 北京时间 <a href=https://xw.qq.com/tech/20200411012101/TEC2020041101210100><strong>腾讯科技&知乎</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>(本文由知乎答主庄有猫撰文,腾讯科技整理,作者系知乎医学话题优秀回答者、日本北海道大学硕士、丁香医生签约作者)4月11日,吉利德在《新英格兰医学》杂志上发布了瑞德西韦(Remdesivir)治疗新冠肺炎(COVID-19)的首个临床研究结果。结果显示,在53名来自美国、欧洲、加拿大及日本的严重和危重新冠肺炎患者中,瑞德西韦给68%(36人)的患者带来临床改善。其中,57%(30/53)接受机械通气...</p>\n\n<a href=\"https://xw.qq.com/tech/20200411012101/TEC2020041101210100\">Web Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"https://inews.gtimg.com/newsapp_ls/0/11571250560_640330/0","relate_stocks":{"GILD":"吉利德科学"},"source_url":"https://xw.qq.com/tech/20200411012101/TEC2020041101210100","is_english":false,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"2026266699","content_text":"(本文由知乎答主庄有猫撰文,腾讯科技整理,作者系知乎医学话题优秀回答者、日本北海道大学硕士、丁香医生签约作者)4月11日,吉利德在《新英格兰医学》杂志上发布了瑞德西韦(Remdesivir)治疗新冠肺炎(COVID-19)的首个临床研究结果。结果显示,在53名来自美国、欧洲、加拿大及日本的严重和危重新冠肺炎患者中,瑞德西韦给68%(36人)的患者带来临床改善。其中,57%(30/53)接受机械通气的患者中有17例已拔管。共有47%(25/53)的患者出院,13%(7/53)患者死亡;在接受有创通气的患者中,死亡率为18%(6/34),而未接受有创通气的患者为5%(1/19)。在安全性方面,总计32名患者(60%)出现副作用,最常见的是肝脏酶指标升高、腹泻、皮疹、肾功能障碍和高血压。总计12名(23%)患者出现严重副作用,其中包括多器官多器官功能障碍综合征、败血性休克、急性肾脏损伤和高血压。先把这个结果的几个重点给大家划出来:-这个公布的是「同情给药」的研究结果,患者都是重症患者,包括需要接受机械通气治疗或者已经上了ECMO的;-在最终收集到的数据中,68%的重症患者获得了临床改善,其中有创机械通气患者的病死率为18%;-总体来说,瑞德西韦可以有效改善重症患者的临床表现,降低机械通气患者的病死率;什么是同情给药?同情给药这是一种基于人道主义的用药方式。很多国家都已经有同情给药制度,标准没有太大差别。根据咱们的标准,同情给药的目标人群是患有危及生命(或者严重影响患者生活质量)的疾病、需早期干预、但是目前无有效治疗手段的疾病的患者。通常来说,一个药物在实验室里开发出来之后,必须经过漫长的临床试验结果才能上市。然而,有些患者病情较重无法入组,或者临床试验尚未获得所在国的批准,而这个时候这个药物可能是他最后的救命稻草。这时候医生会尽一切办法为患者寻找可能有效的药物,哪怕是冒着各种各样的风险,这就催生了“同情给药”制度。在美国,美国的药品审评研究中心每年平均收到1215份同情给药的申请,其中99.5%获批。同情给药,于患者而言是新的希望, 于医生而言是新的武器,然而对于药企本身来说,同情给药往往不是最佳选择。这是因为,接受同情给药的患者通常都是重症患者,病情千变万化,同情给药并不像随机对照双盲临床试验那样,有严格的入组标准来控制变量,因此同情给药的结果往往更加不可控,另外药企还可能面临潜在的法律风险。越年轻,用药效果越好说完同情给药,咱们回到论文本身。下图NEJM这项研究的患者来源,我根据文章的数据简单做了个图。这些新冠肺炎患者都是重症患者,来自美国、欧洲/加拿大和日本,患者的自然吸气氧饱和度低于94%,或者已经开始接受呼吸机治疗。最终除去无法分析8例的患者,在剩下的53位患者中,美国(22位)是最多的,其次是意大利(12位)和日本(9位)。在这53名患者中,有30名患者(57%)正在接受机械通气治疗,而4名(8%)正在接受ECMO治疗。这些患者的临床数据见下图。基线是患者们开始使用瑞德西韦治疗的日期。条状图从深红到浅黄,表示的是患者接收的氧气支持类型,颜色由深到浅分别是:ECMO、机械通气(通常指气管插管)、无创正压通气、高流量输氧、低流量输氧和环境空气(通常指正常呼吸)。一些朋友通过这次疫情知道了有ECMO这种设备,它的重要性可以看下这幅图——ECMO再上去就没有了。简单来说,颜色越深的氧气支持创伤越大,也说明患者情况越重。而左侧的蓝色圆形,表示患者治疗后的状态,分别是改善、不变和恶化;右侧标志,黑色正方形表示死亡,空心菱形表示出院,没标志的代表还在治疗当中。这些重症患者所接受的治疗方式是瑞德西韦静脉输注,治疗首日用的是200mg,次日及之后是100mg,整个疗程为10天。最终结果显示,在53位重症患者当中,有36位患者(68%)的氧气支持情况得到了改善。其中30位(57%)接受气管插管的患者中,有17位已经可以拔管了;而4位原先接受ECMO治疗的患者中,有3位已经脱离ECMO了。53位重症患者中,有25位(47%)已经出院。另外并非所有患者都能获得改善,在对这些重症患者进行同情给药后,7位(13%)患者死亡,尤其是那些在开始接受瑞德西韦治疗时已经进行有创通气(气管插管或ECMO)的患者,这些患者的病死率为18%(6位)。但是,瑞德西韦的同情给药,仍然在很大程度上降低了重症患者的病死率,尤其是已经接受了有创通气的患者。3月13日,金银潭医院在JAMA Intern Med(美国医学会杂志 · 内科学)上发表了一篇研究论文,公布了201名住院患者的治疗情况,这些患者的整体病死率为22%,其中接受有创通气的患者当中病死率更是高达66%。结合论文中的另外两张图,瑞德西韦对于没有接收有创通气的患者以及相对年轻(越年轻、症状越轻的患者,效果越明显。而除了疗效以外,研究人员也详细记录了在治疗过程中患者出现不良反应。总体来说,在治疗过程中,重症患者们主要出现的不良反应有转氨酶升高(23%)、腹泻(9%)、皮疹(8%)、肾功能受损(8%)和低血压(8%)等,像多器官衰竭、感染性休克、急性肾损伤和低血压等严重不良反应各有2名患者出现。具体可以看下面这张图。另外,在论文后面提出了这项研究目前存在的一些不足,例如规模小、随访时间短、由于项目性质而可能出现的遗漏数据、缺乏8名治疗患者的信息以及缺乏随机对照组等。由于是同情给药,患者处于不同的国家、不同的医院,他们所采取的其他治疗方式(如通气操作的变化和辅助药物)也可能有很大的不同。因此,最终的结果,还是要来自随机对照的临床试验。瑞德西韦可能会被考虑作为临床一线用药实际上,瑞德西韦在这次同情给药的效果比预想的更好。瑞德西韦本质上是一种核苷类似物,通过阻止病毒RNA复制而发挥作用。从原理上来说 ,瑞德西韦对于新冠肺炎发病初期的患者来说,效果会更好,对于重症患者的效果可能不佳,因为重症患者的很多症状并非来自于新冠病毒本身,而是来自于人体的细胞因子风暴等现象。简单来说,就是人体免疫系统杀敌八百,自损三千。如果在后续揭盲的随机对照临床试验中,重症患者能出现和这次同情给药类似的改善效果,在目前其他抗病毒药物都未体现出更好效果的时候,瑞德西韦可能会被考虑作为临床一线用药。","news_type":1},"isVote":1,"tweetType":1,"viewCount":2341,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":925117621,"gmtCreate":1587887576263,"gmtModify":1704365734507,"author":{"id":"51471756433604","authorId":"51471756433604","name":"韭菜PIKA","avatar":"https://static.laohu8.com/8790a4e6a56229acc72938aca19079cc","crmLevel":1,"crmLevelSwitch":0,"followedFlag":false},"themes":[],"htmlText":"港片《风云当当》上演","listText":"港片《风云当当》上演","text":"港片《风云当当》上演","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":2,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/925117621","repostId":"1132934930","repostType":4,"repost":{"id":"1132934930","pubTimestamp":1587885274,"share":"https://www.laohu8.com/m/news/1132934930?lang=&edition=full","pubTime":"2020-04-26 15:14","market":"us","language":"zh","title":"李国庆发告全体员工书:本人全面接管公司","url":"https://stock-news.laohu8.com/highlight/detail?id=1132934930","media":"新浪财经","summary":"4月26日消息,据我是律师的朋友、首席内幕官等微博大V爆料,李国庆今日率4条大汉上门抢当当公章。并在公司张贴《告当当网全体员工书》,告员工书指出,李国庆全面接管公司,负责公司的经营管理。俞渝不再担任当","content":"<p>4月26日消息,据我是律师的朋友、首席内幕官等微博大V爆料,李国庆今日率4条大汉上门抢当当公章。并在公司张贴《告当当网全体员工书》,告员工书指出,李国庆全面接管公司,负责公司的经营管理。俞渝不再担任当当公司执行董事、法定代表人及总经理。俞渝无权在当当公司公司形式任何职权,无权向当当员工发出任何指示,无权代表当当公司对外做出任何意思表示或者行为。</p><p>划重点:</p><p>1.李国庆出于维护当当大局和家庭关系的维系等因素,禅让公司管理权3年。</p><p>2.俞渝拒绝给股东分红,在公司连续5年盈利的情况下从不分红。</p><p>3.新冠肺炎疫情期间,当当网员工确诊。六十余名员工被集中隔离观察,二百余名员工居家隔离观察。</p><p>4.李国庆于2020年4月24日召开临时股东会,并作出决议:公司依法成立董事会。</p><p>5.自2020年4月24日起,俞渝不再担任当当公司执行董事、法定代表人及总经理。俞渝无权在当当公司公司形式任何职权,无权向当当员工发出任何指示,无权代表当当公司对外做出任何意思表示或者行为。</p><p>6.李国庆全面接管公司,负责公司的经营管理。</p><p>同时宣布以下决定:</p><p>1.自2020年2月1日始至今,以“开除、辞退、优化”等方式的人事流程全部终止,已被单方面辞退的员工,可与公司协商,协商一致重新签署劳动合同返岗。</p><p>2. 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href=\"https://finance.sina.com.cn/chanjing/gsnews/2020-04-26/doc-iirczymi8428893.shtml\">Web Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"https://static.tigerbbs.com/2ca5a0b68bdcd00f3117962abbedc90e","relate_stocks":{},"source_url":"https://finance.sina.com.cn/chanjing/gsnews/2020-04-26/doc-iirczymi8428893.shtml","is_english":false,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1132934930","content_text":"4月26日消息,据我是律师的朋友、首席内幕官等微博大V爆料,李国庆今日率4条大汉上门抢当当公章。并在公司张贴《告当当网全体员工书》,告员工书指出,李国庆全面接管公司,负责公司的经营管理。俞渝不再担任当当公司执行董事、法定代表人及总经理。俞渝无权在当当公司公司形式任何职权,无权向当当员工发出任何指示,无权代表当当公司对外做出任何意思表示或者行为。划重点:1.李国庆出于维护当当大局和家庭关系的维系等因素,禅让公司管理权3年。2.俞渝拒绝给股东分红,在公司连续5年盈利的情况下从不分红。3.新冠肺炎疫情期间,当当网员工确诊。六十余名员工被集中隔离观察,二百余名员工居家隔离观察。4.李国庆于2020年4月24日召开临时股东会,并作出决议:公司依法成立董事会。5.自2020年4月24日起,俞渝不再担任当当公司执行董事、法定代表人及总经理。俞渝无权在当当公司公司形式任何职权,无权向当当员工发出任何指示,无权代表当当公司对外做出任何意思表示或者行为。6.李国庆全面接管公司,负责公司的经营管理。同时宣布以下决定:1.自2020年2月1日始至今,以“开除、辞退、优化”等方式的人事流程全部终止,已被单方面辞退的员工,可与公司协商,协商一致重新签署劳动合同返岗。2. 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