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2021-09-23

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Moderna vs Pfizer: Both knockouts, but one seems to have the edge

NEW YORK (NYTIMES) - It was a constant refrain from federal health officials after the coronavirus v

Moderna vs Pfizer: Both knockouts, but one seems to have the edge

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In a half-dozen studies published over the past few weeks, Moderna's vaccine appeared to be more protective than the Pfizer-BioNTech vaccine in the months after immunisation.\nThe latest such study, published on Wednesday (Sept 22) in The New England Journal of Medicine, evaluated the real-world effectiveness of the vaccines at preventing symptomatic illness in about 5,000 health care workers in 25 states. The study found that the Pfizer-BioNTech vaccine had an effectiveness of 88.8 per cent, compared with Moderna's 96.3 per cent.\nResearch published on Friday by the Centres for Disease Control and Prevention found that the efficacy of the Pfizer-BioNTech vaccine against hospitalisation fell from 91 per cent to 77 per cent after a four-month period following the second shot. The Moderna vaccine showed no decline over the same period.\nIf the efficacy gap continues to widen, it may have implications for the debate on booster shots. Federal agencies this week are evaluating the need for a third shot of the Pfizer-BioNTech vaccine for some high-risk groups, including older adults.\nScientists who were initially sceptical of the reported differences between the Moderna and Pfizer-BioNTech vaccines have slowly become convinced that the disparity is small but real.\n\"Our baseline assumption is that the mRNA vaccines are functioning similarly, but then you start to see a separation,\" said Natalie Dean, a biostatistician at Emory University in Atlanta. \"It's not a huge difference, but at least it's consistent.\"\nBut the discrepancy is small and the real-world consequences uncertain, because both vaccines are still highly effective at preventing severe illness and hospitalisation, she and others cautioned.\n\"Yes, likely a real difference, probably reflecting what's in the two vials,\" said John Moore, a virus expert at Weill Cornell Medicine in New York. \"But truly, how much does this difference matter in the real world?\"\n\"It's not appropriate for people who took Pfizer to be freaking out that they got an inferior vaccine.\"\nEven in the original clinical trials of the three vaccines eventually authorised in the United States - made by Pfizer-BioNTech, Moderna and Johnson & Johnson - it was clear that the J&J vaccine had a lower efficacy than the other two. Research since then has borne out that trend, although J&J announced this week that a second dose of its vaccine boosts its efficacy to levels comparable to the others.\nThe Pfizer-BioNTech and Moderna vaccines rely on the same mRNA platform, and in the initial clinical trials, they had remarkably similar efficacy against symptomatic infection: 95 per cent for Pfizer-BioNTech and 94 per cent for Moderna. This was in part why they were described as more or less equivalent.","news_type":1},"isVote":1,"tweetType":1,"viewCount":85,"commentLimit":10,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"symbols":[],"verified":2,"subType":0,"readableState":1,"langContent":"EN","currentLanguage":"EN","warmUpFlag":false,"orderFlag":false,"shareable":true,"causeOfNotShareable":"","featuresForAnalytics":[],"commentAndTweetFlag":false,"andRepostAutoSelectedFlag":false,"upFlag":false,"length":3,"xxTargetLangEnum":"ORIG"},"commentList":[],"hasMoreComment":false,"orderType":2}