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LY1970
2021-12-21

Pardes to go public, says COVID-19 antiviral pill does not need booster

(Reuters) - Pardes Biosciences on Tuesday said early human testing shows that its experimental COVID

Pardes to go public, says COVID-19 antiviral pill does not need booster

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It aims to begin by mid-year a larger trial that could be used to seek regulatory approval for the COVID-19 antiviral pill.</p>\n<p>There are currently no authorized oral COVID-19 treatments. But they are expected to become important tools against the illness because they can be taken at home early after symptoms appear to keep people out of the hospital.</p>\n<p>The Pardes drug is a protease inhibitor, designed to prevent the coronavirus from replicating in human cells. That is the same class of medicine as Pfizer's nirmatrelvir, which in combination with the older antiviral ritonavir was shown to cut the risk of hospitalization or death by 89% for COVID-19 patients at high risk of severe illness.</p>\n<p>Ritonavir is used to extend the action of the Pfizer pill, but can also interfere with some other medicines a patient may be taking, raising the risk of complications.</p>\n<p>\"We believe the ability to have an unboosted regimen will be important,\" Pardes Chief Executive Officer Uri Lopatin told Reuters. He said that in the United States, <a href=\"https://laohu8.com/S/AONE.U\">one</a> in five adults are on at least one prescription medication.</p>\n<p>Pfizer, which says the issue of drug-drug interactions is manageable, is awaiting emergency authorization from the FDA for Paxlovid.</p>\n<p>\"If you look at hepatitis C and HIV as proxies for COVID, you'll see first generation compounds come out and then over time you'll see better and better options,\" said Jim Tananbaum, founder and CEO of healthcare investment firm Foresite Capital.</p>\n<p>Some newer hepatitis C drugs were considered to be advances in part because they were highly effective without the need for ritonavir.</p>\n<p>Foresite is the sponsor of FS Development Corp II, a so-called blank check company set up to raise cash for acquisitions as an alternative to a traditional initial public offering. A shareholder vote on the merger of Pardes and FS II is scheduled for Thursday.</p>\n<p>Company officials said Pardes is in talks with regulators about the design of a larger, global trial of PBI-0451, including the number of participants and geographic locations.</p>","source":"yahoofinance","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>Pardes to go public, says COVID-19 antiviral pill does not need booster</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nPardes to go public, says COVID-19 antiviral pill does not need booster\n</h2>\n\n<h4 class=\"meta\">\n\n\n2021-12-21 19:45 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://finance.yahoo.com/news/exclusive-pardes-public-says-covid-110626887.html><strong>Reuters</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>(Reuters) - Pardes Biosciences on Tuesday said early human testing shows that its experimental COVID-19 antiviral pill works as a standalone treatment and announced plans to go public by merging with ...</p>\n\n<a href=\"https://finance.yahoo.com/news/exclusive-pardes-public-says-covid-110626887.html\">Web Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"BK4007":"制药","BK4533":"AQR资本管理(全球第二大对冲基金)","BK4534":"瑞士信贷持仓","PRDS":"Pardes Biosciences Inc.","BK4550":"红杉资本持仓","PFE":"辉瑞","BK4568":"美国抗疫概念"},"source_url":"https://finance.yahoo.com/news/exclusive-pardes-public-says-covid-110626887.html","is_english":true,"share_image_url":"https://static.laohu8.com/5f26f4a48f9cb3e29be4d71d3ba8c038","article_id":"2193151218","content_text":"(Reuters) - Pardes Biosciences on Tuesday said early human testing shows that its experimental COVID-19 antiviral pill works as a standalone treatment and announced plans to go public by merging with a special purpose acquisition company.\nIf the drug, called PBI-0451, proves effective in later-stage testing, it could have an advantage over similar pills that need to be taken with a second, booster medication, such as the Pfizer Inc two-drug antiviral regimen, Paxlovid, now under consideration by the U.S. Food and Drug Administration.\nPardes said it expects to complete its current Phase I study in healthy volunteers early next year. It aims to begin by mid-year a larger trial that could be used to seek regulatory approval for the COVID-19 antiviral pill.\nThere are currently no authorized oral COVID-19 treatments. But they are expected to become important tools against the illness because they can be taken at home early after symptoms appear to keep people out of the hospital.\nThe Pardes drug is a protease inhibitor, designed to prevent the coronavirus from replicating in human cells. That is the same class of medicine as Pfizer's nirmatrelvir, which in combination with the older antiviral ritonavir was shown to cut the risk of hospitalization or death by 89% for COVID-19 patients at high risk of severe illness.\nRitonavir is used to extend the action of the Pfizer pill, but can also interfere with some other medicines a patient may be taking, raising the risk of complications.\n\"We believe the ability to have an unboosted regimen will be important,\" Pardes Chief Executive Officer Uri Lopatin told Reuters. He said that in the United States, one in five adults are on at least one prescription medication.\nPfizer, which says the issue of drug-drug interactions is manageable, is awaiting emergency authorization from the FDA for Paxlovid.\n\"If you look at hepatitis C and HIV as proxies for COVID, you'll see first generation compounds come out and then over time you'll see better and better options,\" said Jim Tananbaum, founder and CEO of healthcare investment firm Foresite Capital.\nSome newer hepatitis C drugs were considered to be advances in part because they were highly effective without the need for ritonavir.\nForesite is the sponsor of FS Development Corp II, a so-called blank check company set up to raise cash for acquisitions as an alternative to a traditional initial public offering. A shareholder vote on the merger of Pardes and FS II is scheduled for Thursday.\nCompany officials said Pardes is in talks with regulators about the design of a larger, global trial of PBI-0451, including the number of participants and geographic locations.","news_type":1},"isVote":1,"tweetType":1,"viewCount":1394,"commentLimit":10,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"symbols":[],"verified":2,"subType":0,"readableState":1,"langContent":"CN","currentLanguage":"CN","warmUpFlag":false,"orderFlag":false,"shareable":true,"causeOfNotShareable":"","featuresForAnalytics":[],"commentAndTweetFlag":false,"andRepostAutoSelectedFlag":false,"upFlag":false,"length":2,"xxTargetLangEnum":"ZH_CN"},"commentList":[],"hasMoreComment":false,"orderType":2}