Britain approves Merck's Covid-19 pill in world first_老虎社区_美港股上老虎

Britain approves Merck's Covid-19 pill in world first

The Straits Times2021-11-05

Nov 4 (Reuters) - Britain on Thursday became the first country in the world to approve a potentially game-changing COVID-19 antiviral pill jointly developed by U.S.-based Merck & Co Inc(MRK.N)and ...

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mseokt
·2021-11-05
Hopefully the pill is effective
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U.S. advisers will meet on Nov. 30 to review the drug's safety and efficacy data and vote on whether molnupiravir should be authorized.read more\nThe pill, which will be branded as Lagevrio in Britain, is designed to introduce errors into the genetic code of the coronavirus that causes COVID-19 and is taken twice a day for five days.\nDrugs in the same class as molnupiravir have been linked to birth defects in animal studies. Merck, known as MSD outside of the United States and Canada, has said animal testing shows that molnupiravir is safe, but the data have not yet been made public.\nTreatments to tackle the pandemic, which has killed more than 5.2 million people worldwide, have so far focused mainly on vaccines. Other options, including Gilead's(GILD.O)infused antiviral remdesivir and generic steroid dexamethasone, are generally only given after a patient has been hospitalised.\nMerck's Molnupiravir has been closely watched since data last month showed it could halve the chances of dying or being hospitalised for those most at risk of developing severe COVID-19 when given early in the illness.\nProfessor Stephen Powis, national medical director for the National Health Service (NHS) in England, said the drug would be administered to patients at higher risk of complications as Britain heads into one of the most challenging winters ever.\nA wider rollout will follow if it is clinically and cost effective in reducing hospitalisations and death, he added.\n\"We are now working across government and the NHS to urgently get this treatment to patients initially through a national study so we can collect more data on how antivirals work in a mostly vaccinated population,\" UK vaccines minister Maggie Throup told parliament.\nPRESSURES\nThe speedy approval in Britain, which was also the first Western country to approve a COVID-19 vaccine, comes as it struggles to tame soaring infections.\nBritain has about 40,000 daily cases of COVID-19, according to the latest seven-day average. That is second only to the roughly 74,000 a day in the United States, which has five times more people, and has fuelled criticism of the government's decision to abandon most pandemic-related restrictions\nData released on Wednesday night showed COVID-19 prevalence in England hit its highest level on record last month, led by a high number of cases in children and a surge in the south-west of the country.\nPressure is growing on the government to implement its \"Plan B\" aimed at protecting the NHS from unsustainable demands, involving mask mandates, vaccine passes and work-from-home orders.\nMany other big economies, including Germany, France and Israel, have either retained some basic COVID-19 measures like mask mandates or reintroduced them in response to rising cases.\nThe UK government has said its focus remains on administering vaccine boosters and inoculating 12- to 15-year-olds.\n\"With no compromises on quality, safety and effectiveness, the public can trust that the MHRA has conducted a robust and thorough assessment of the data (on molnupiravir),\" MHRA chief June Raine said in a statement.\nLast month, Britain agreed a deal with Merck tosecure480,000 courses of molnupiravir.\nProfessor Penny Ward, an independent pharmaceutical physician, welcomed the approval, but said the NHS needed to outline its plans for rollout and cautioned that supplies were likely to be tight given the strong global demand.\n\"Comments made by Mr Javid today suggest that it may be made available via a clinical trial, presumably to investigate its effectiveness in vaccinated patients with breakthrough infections, as the original study incorporated unvaccinated adults,\" she said.\nIf given to everyone becoming unwell, the nearly half a million courses would not last very long given the more than 40,000 current daily case rate, she said.\nTREATMENT RACE\nIn a separate statement, Merck said it expected to produce 10 million courses of the treatment by the end of this year, with at least 20 million set to be manufactured in 2022.\nThe U.S.-based drugmaker's shares rose 2.1% to close at $90.54 on Thursday.\nPfizer(PFE.N)and Roche(ROG.S)are also racing to develop easy-to-administer antiviral pills for COVID-19.\nBoth Merck and Pfizer are studying their drugs in late-stage trials for preventing coronavirus infection.\nViral sequencing done so far has shown molnupiravir is effective against all variants of the coronavirus, Merck has said, including the more-infectious Delta, which is responsible for the worldwide surge in hospitalisations and deaths recently.\nWhile it is not yet clear when Merck will deliver doses to Britain, the company has said it is committed to providing timely access to its drug globally with plans for tiered pricing aligned with a country's ability to pay.\nMerck has licensed the drug to generic drugmakers for supply to low-income countries.\nAntibody cocktails like those from Regeneron(REGN.O)and Eli Lilly(LLY.N)have also been approved for non-hospitalised COVID-19 patients, but have to be given intravenously.","kind":null,"is_publish_news":true,"is_publish_highlight":true,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[{"id":846682292,"gmtCreate":1636078065172,"gmtModify":1636079495059,"author":{"id":"3577447162748311","authorId":"3577447162748311","authorIdStr":"3577447162748311","name":"mseokt","avatar":"https://static.laohu8.com/default-avatar.jpg","vip":1,"crmLevel":2,"crmLevelSwitch":0},"htmlText":"Hopefully the pill is effective&nbsp;","listText":"Hopefully the pill is effective&nbsp;","text":"Hopefully the pill is effective","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/846682292","repostId":2180795475,"repostType":4,"isVote":1,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"tweetType":1,"langContent":"CN"}],"hasMoreComments":true,"newsSizeData":{"likeSize":59,"commentSize":1,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false}}