Novartis, Molecular Partners report positive early-stage results of COVID-19 antiviral therapy, ensovibep_老虎社区_美港股上老虎

Novartis, Molecular Partners report positive early-stage results of COVID-19 antiviral therapy, ensovibep

seekingalpha2021-03-09

Molecular Partners(OTCPK:MLLCF)and itscollaboratorNovartis(NYSE:NVS)announced initial results from their ongoing phase 1 study of first tri-specificCOVID-19 antiviral treatment, ensovibep (MP0420), in...

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maltose123
·2021-03-09
mdndhd
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Jerkkid
·2021-03-09
Good!
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itscollaboratorNovartis(NYSE:NVS)announced initial results from their ongoing phase 1 study of first tri-specificCOVID-19 antiviral treatment, ensovibep (MP0420), in...</p>\n\n<a href=\"https://seekingalpha.com/news/3670544-novartis-molecular-partners-report-positive-early-stage-results-of-covid-19-antiviral-therapy-ensovibep\">Web Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"MLLCF":"Molecular Partners AG","NVS":"诺华"},"source_url":"https://seekingalpha.com/news/3670544-novartis-molecular-partners-report-positive-early-stage-results-of-covid-19-antiviral-therapy-ensovibep","is_english":true,"share_image_url":"https://static.laohu8.com/5a36db9d73b4222bc376d24ccc48c8a4","article_id":"1168910610","content_text":"Molecular Partners(OTCPK:MLLCF)and itscollaboratorNovartis(NYSE:NVS)announced initial results from their ongoing phase 1 study of first tri-specificCOVID-19 antiviral treatment, ensovibep (MP0420), in healthy volunteers.Healthy volunteers were randomized 3:1 to receive ensovibep or placebo, respectively.Two dosing cohorts with 8 patients per dose cohort have been fully enrolled and received a single infusion of 3mg or 9mg per kilogram body weight.In each of these cohorts, ensovibep was seen to be safe and well tolerated, with no significant adverse events reported.Preliminary results showed extended exposure of the DARPin candidate in serum, with a half-life of 2-3 weeks.These data support advanced plans for additional clinical work in positively diagnosed patients.The companies looks forward to initiate phase 2/3 global registration study, early in Q2.Per protocol, a third cohort at a 20mg per kilogram dose level has been planned.In October 2020, Molecular Partners and Novartis collaborated to developtwo DARPin therapies for 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margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nNovartis, Molecular Partners report positive early-stage results of COVID-19 antiviral therapy, ensovibep\n</h2>\n\n<h4 class=\"meta\">\n\n\n2021-03-09 14:48 GMT+8&nbsp;&nbsp;&nbsp;<a href=https://seekingalpha.com/news/3670544-novartis-molecular-partners-report-positive-early-stage-results-of-covid-19-antiviral-therapy-ensovibep><strong>seekingalpha</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>Molecular Partners(OTCPK:MLLCF)and itscollaboratorNovartis(NYSE:NVS)announced initial results from their ongoing phase 1 study of first tri-specificCOVID-19 antiviral treatment, ensovibep (MP0420), in...</p>\n\n<a href=\"https://seekingalpha.com/news/3670544-novartis-molecular-partners-report-positive-early-stage-results-of-covid-19-antiviral-therapy-ensovibep\">Web Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"","relate_stocks":{"MLLCF":"Molecular Partners AG","NVS":"诺华"},"source_url":"https://seekingalpha.com/news/3670544-novartis-molecular-partners-report-positive-early-stage-results-of-covid-19-antiviral-therapy-ensovibep","is_english":true,"share_image_url":"https://static.laohu8.com/5a36db9d73b4222bc376d24ccc48c8a4","article_id":"1168910610","content_text":"Molecular Partners(OTCPK:MLLCF)and itscollaboratorNovartis(NYSE:NVS)announced initial results from their ongoing phase 1 study of first tri-specificCOVID-19 antiviral treatment, ensovibep (MP0420), in healthy volunteers.Healthy volunteers were randomized 3:1 to receive ensovibep or placebo, respectively.Two dosing cohorts with 8 patients per dose cohort have been fully enrolled and received a single infusion of 3mg or 9mg per kilogram body weight.In each of these cohorts, ensovibep was seen to be safe and well tolerated, with no significant adverse events reported.Preliminary results showed extended exposure of the DARPin candidate in serum, with a half-life of 2-3 weeks.These data support advanced plans for additional clinical work in positively diagnosed patients.The companies looks forward to initiate phase 2/3 global registration study, early in Q2.Per protocol, a third cohort at a 20mg per kilogram dose level has been planned.In October 2020, Molecular Partners and Novartis collaborated to developtwo DARPin therapies for COVID-19.","news_type":1},"isVote":1,"likeStatus":false,"favoriteStatus":false,"reportStatus":false,"tweetType":1,"langContent":"EN"}],"hasMoreComments":true,"newsSizeData":{"likeSize":9,"commentSize":2,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false}}