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爱喝普洱的小兔子
07-10
$特斯拉(TSLA)$
家人们 我好害怕😱 我做了call
爱喝普洱的小兔子
04-07
$苹果(AAPL)$
苹果能不能出个LCD屏,现在的屏幕也太闪了.
爱喝普洱的小兔子
2021-04-01
这篇文章不错,转发给大家看看
抱歉,原内容已删除
爱喝普洱的小兔子
2021-02-22
这篇文章不错,转发给大家看看
抱歉,原内容已删除
爱喝普洱的小兔子
2021-02-12
$Sundial Growers Inc.(SNDL)$
心好累,删app了,做个鸵鸟.上次蔚来也是这样.要不然怎么拿到50,说不定9块钱就卖了.
爱喝普洱的小兔子
2021-02-03
$Sundial Growers Inc.(SNDL)$
看到10:30的时候好多100万的买入,导致我有点信心了
爱喝普洱的小兔子
2021-01-29
$Sundial Growers Inc.(SNDL)$
昨天我看NAKD从四毛长到三块,然而我没有下手.主要是我觉得s n d l 可以有三块钱,于是下手了,感觉一块钱的成本说贵不贵,说便宜也不便宜.
爱喝普洱的小兔子
2021-01-28
$Sundial Growers Inc.(SNDL)$
为啥停牌了?
爱喝普洱的小兔子
2021-01-26
$Palantir Technologies Inc.(PLTR)$
看这分时图,这熟悉的配方,又来了
爱喝普洱的小兔子
2021-01-26
$Palantir Technologies Inc.(PLTR)$
我觉得这里老温和了,隔壁GME,才玩的是心跳
爱喝普洱的小兔子
2020-12-12
这篇文章不错,转发给大家看看
@坡上之云阿龙:财务自由:美股期权教学 老虎第一人
爱喝普洱的小兔子
2020-12-12
这篇文章不错,转发给大家看看
@坡上之云阿龙:财务自由:美股期权教学 老虎第一人
爱喝普洱的小兔子
2020-12-12
$Palantir Technologies Inc.(PLTR)$
这跌不下去,怎么加仓
爱喝普洱的小兔子
2020-12-08
这篇文章不错,转发给大家看看
@换汤不换药:美股上市药企分析—Mersana Therapeutics
爱喝普洱的小兔子
2020-12-07
这篇文章不错,转发给大家看看
@小虎活动:2020年老虎年度人物评选开始啦,即刻投出所爱!
去老虎APP查看更多动态
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","listText":"<a href=\"https://laohu8.com/S/SNDL\">$Sundial Growers Inc.(SNDL)$</a>为啥停牌了? ","text":"$Sundial Growers Inc.(SNDL)$为啥停牌了?","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/318130340","isVote":1,"tweetType":1,"viewCount":1382,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":319425992,"gmtCreate":1611600600216,"gmtModify":1703751567767,"author":{"id":"3548930401820895","authorId":"3548930401820895","name":"爱喝普洱的小兔子","avatar":"https://static.tigerbbs.com/83de70ea332657d3bb5b922b18e5afad","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"idStr":"3548930401820895","authorIdStr":"3548930401820895"},"themes":[],"htmlText":"<a href=\"https://laohu8.com/S/PLTR\">$Palantir Technologies Inc.(PLTR)$</a>看这分时图,这熟悉的配方,又来了","listText":"<a href=\"https://laohu8.com/S/PLTR\">$Palantir Technologies Inc.(PLTR)$</a>看这分时图,这熟悉的配方,又来了","text":"$Palantir Technologies Inc.(PLTR)$看这分时图,这熟悉的配方,又来了","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":6,"commentSize":4,"repostSize":0,"link":"https://laohu8.com/post/319425992","isVote":1,"tweetType":1,"viewCount":4700,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":319484518,"gmtCreate":1611595650934,"gmtModify":1703751544817,"author":{"id":"3548930401820895","authorId":"3548930401820895","name":"爱喝普洱的小兔子","avatar":"https://static.tigerbbs.com/83de70ea332657d3bb5b922b18e5afad","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"idStr":"3548930401820895","authorIdStr":"3548930401820895"},"themes":[],"htmlText":"<a href=\"https://laohu8.com/S/PLTR\">$Palantir Technologies Inc.(PLTR)$</a>我觉得这里老温和了,隔壁GME,才玩的是心跳","listText":"<a href=\"https://laohu8.com/S/PLTR\">$Palantir Technologies Inc.(PLTR)$</a>我觉得这里老温和了,隔壁GME,才玩的是心跳","text":"$Palantir Technologies Inc.(PLTR)$我觉得这里老温和了,隔壁GME,才玩的是心跳","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":5,"commentSize":2,"repostSize":0,"link":"https://laohu8.com/post/319484518","isVote":1,"tweetType":1,"viewCount":2322,"authorTweetTopStatus":1,"verified":2,"comments":[{"author":{"id":"3527464863063749","authorId":"3527464863063749","name":"jide0603","avatar":"https://static.laohu8.com/default-avatar.jpg","crmLevel":1,"crmLevelSwitch":0,"idStr":"3527464863063749","authorIdStr":"3527464863063749"},"content":"这边机构带散户玩 那边散户带机构玩 头一次看到散户把机构short squeeze了","text":"这边机构带散户玩 那边散户带机构玩 头一次看到散户把机构short squeeze了","html":"这边机构带散户玩 那边散户带机构玩 头一次看到散户把机构short squeeze了"}],"imageCount":0,"langContent":"CN","totalScore":0},{"id":395703271,"gmtCreate":1607741727493,"gmtModify":1703849750588,"author":{"id":"3548930401820895","authorId":"3548930401820895","name":"爱喝普洱的小兔子","avatar":"https://static.tigerbbs.com/83de70ea332657d3bb5b922b18e5afad","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"idStr":"3548930401820895","authorIdStr":"3548930401820895"},"themes":[],"htmlText":"这篇文章不错,转发给大家看看","listText":"这篇文章不错,转发给大家看看","text":"这篇文章不错,转发给大家看看","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/395703271","repostId":"395700180","repostType":1,"repost":{"id":395700180,"gmtCreate":1607740431440,"gmtModify":1728102290861,"author":{"id":"84591292386623","authorId":"84591292386623","name":"坡上之云阿龙","avatar":"https://static.tigerbbs.com/23192029e6cace475a85ecd015bbf903","crmLevel":6,"crmLevelSwitch":0,"followedFlag":false,"idStr":"84591292386623","authorIdStr":"84591292386623"},"themes":[],"title":"财务自由:美股期权教学 老虎第一人","htmlText":"美股期权交易基础最近很想把做股票期权(Option)的积累的认识,想法写下来,希望帮助那些想要进行Option交易的和刚刚入门的人。也希望有高手能够交流分享,指导。首先需要解决几个基本问题:(1)什么是股票期权 (Option)股票期权是一种建立在买方和卖方之间合约或叫约定。这种合约给了买方在特定价格(Strike Price)买入或卖出一只股票的权利。当然这种合约是有期限的。有可能是一个星期,也有可能是一个月,几个月或是一年两年。当合约到期日那天,持有股票期权的买方有权选择执行股票期权或是让股票期权作废。当然在合约到期日之前,持有股票期权的买方还可以卖出所持有的股票期权,卖出股票期权的卖方也可以买回期权平仓。(2)有几种股票期权两种。看涨期权又叫Call和看跌期权又叫Put(3)股票期权怎么交易股票期权的买卖单位是以一个合约为单位的(contract)。一个合约代表了100股股票的权利。如果我买了2个一个月后到期的股票ABC的看涨期权(Call)合约,表示一个月后股票期权到期日时,我有权买入200股ABC。如果股票期权价格为$1每股,买入1个合约的成本是:$1 x 100 = $100从交易方法来看,可以有4种方法:买入看涨期权(Long Call):看涨股票时,一般可以买入看涨期权买入看跌期权(Long Put):看跌股票时,一般可以买入看跌期权卖出看涨期权(Short Call):看跌股票时,可以卖出看涨期权。高风险卖出看跌期权(Short Put):看涨股票时,可以卖出看跌期权。高风险例:如有一只股票ABC 现在价格$10每股,我花$1每股买入了一个月后到期的$12的看涨期权(Call),一个月后ABC涨到了$15每股,我会选择执行我的看涨期权。这样我可以花$12每股买入ABC(至于谁会卖给我,我不用管),而ABC的市场价格已经是$15每股了,所以马上卖出ABC的话","listText":"美股期权交易基础最近很想把做股票期权(Option)的积累的认识,想法写下来,希望帮助那些想要进行Option交易的和刚刚入门的人。也希望有高手能够交流分享,指导。首先需要解决几个基本问题:(1)什么是股票期权 (Option)股票期权是一种建立在买方和卖方之间合约或叫约定。这种合约给了买方在特定价格(Strike Price)买入或卖出一只股票的权利。当然这种合约是有期限的。有可能是一个星期,也有可能是一个月,几个月或是一年两年。当合约到期日那天,持有股票期权的买方有权选择执行股票期权或是让股票期权作废。当然在合约到期日之前,持有股票期权的买方还可以卖出所持有的股票期权,卖出股票期权的卖方也可以买回期权平仓。(2)有几种股票期权两种。看涨期权又叫Call和看跌期权又叫Put(3)股票期权怎么交易股票期权的买卖单位是以一个合约为单位的(contract)。一个合约代表了100股股票的权利。如果我买了2个一个月后到期的股票ABC的看涨期权(Call)合约,表示一个月后股票期权到期日时,我有权买入200股ABC。如果股票期权价格为$1每股,买入1个合约的成本是:$1 x 100 = $100从交易方法来看,可以有4种方法:买入看涨期权(Long Call):看涨股票时,一般可以买入看涨期权买入看跌期权(Long Put):看跌股票时,一般可以买入看跌期权卖出看涨期权(Short Call):看跌股票时,可以卖出看涨期权。高风险卖出看跌期权(Short Put):看涨股票时,可以卖出看跌期权。高风险例:如有一只股票ABC 现在价格$10每股,我花$1每股买入了一个月后到期的$12的看涨期权(Call),一个月后ABC涨到了$15每股,我会选择执行我的看涨期权。这样我可以花$12每股买入ABC(至于谁会卖给我,我不用管),而ABC的市场价格已经是$15每股了,所以马上卖出ABC的话","text":"美股期权交易基础最近很想把做股票期权(Option)的积累的认识,想法写下来,希望帮助那些想要进行Option交易的和刚刚入门的人。也希望有高手能够交流分享,指导。首先需要解决几个基本问题:(1)什么是股票期权 (Option)股票期权是一种建立在买方和卖方之间合约或叫约定。这种合约给了买方在特定价格(Strike Price)买入或卖出一只股票的权利。当然这种合约是有期限的。有可能是一个星期,也有可能是一个月,几个月或是一年两年。当合约到期日那天,持有股票期权的买方有权选择执行股票期权或是让股票期权作废。当然在合约到期日之前,持有股票期权的买方还可以卖出所持有的股票期权,卖出股票期权的卖方也可以买回期权平仓。(2)有几种股票期权两种。看涨期权又叫Call和看跌期权又叫Put(3)股票期权怎么交易股票期权的买卖单位是以一个合约为单位的(contract)。一个合约代表了100股股票的权利。如果我买了2个一个月后到期的股票ABC的看涨期权(Call)合约,表示一个月后股票期权到期日时,我有权买入200股ABC。如果股票期权价格为$1每股,买入1个合约的成本是:$1 x 100 = $100从交易方法来看,可以有4种方法:买入看涨期权(Long Call):看涨股票时,一般可以买入看涨期权买入看跌期权(Long Put):看跌股票时,一般可以买入看跌期权卖出看涨期权(Short Call):看跌股票时,可以卖出看涨期权。高风险卖出看跌期权(Short Put):看涨股票时,可以卖出看跌期权。高风险例:如有一只股票ABC 现在价格$10每股,我花$1每股买入了一个月后到期的$12的看涨期权(Call),一个月后ABC涨到了$15每股,我会选择执行我的看涨期权。这样我可以花$12每股买入ABC(至于谁会卖给我,我不用管),而ABC的市场价格已经是$15每股了,所以马上卖出ABC的话","images":[{"img":"https://static.tigerbbs.com/2c1b9bf77aa1a8605d56b00a664b27d0","width":"1242","height":"2208"}],"top":1,"highlighted":2,"essential":1,"paper":2,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/395700180","isVote":1,"tweetType":1,"viewCount":0,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":2,"langContent":"CN","totalScore":0},"isVote":1,"tweetType":1,"viewCount":1234,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":395709445,"gmtCreate":1607741224987,"gmtModify":1703849749057,"author":{"id":"3548930401820895","authorId":"3548930401820895","name":"爱喝普洱的小兔子","avatar":"https://static.tigerbbs.com/83de70ea332657d3bb5b922b18e5afad","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"idStr":"3548930401820895","authorIdStr":"3548930401820895"},"themes":[],"htmlText":"这篇文章不错,转发给大家看看","listText":"这篇文章不错,转发给大家看看","text":"这篇文章不错,转发给大家看看","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/395709445","repostId":"395700180","repostType":1,"repost":{"id":395700180,"gmtCreate":1607740431440,"gmtModify":1728102290861,"author":{"id":"84591292386623","authorId":"84591292386623","name":"坡上之云阿龙","avatar":"https://static.tigerbbs.com/23192029e6cace475a85ecd015bbf903","crmLevel":6,"crmLevelSwitch":0,"followedFlag":false,"idStr":"84591292386623","authorIdStr":"84591292386623"},"themes":[],"title":"财务自由:美股期权教学 老虎第一人","htmlText":"美股期权交易基础最近很想把做股票期权(Option)的积累的认识,想法写下来,希望帮助那些想要进行Option交易的和刚刚入门的人。也希望有高手能够交流分享,指导。首先需要解决几个基本问题:(1)什么是股票期权 (Option)股票期权是一种建立在买方和卖方之间合约或叫约定。这种合约给了买方在特定价格(Strike Price)买入或卖出一只股票的权利。当然这种合约是有期限的。有可能是一个星期,也有可能是一个月,几个月或是一年两年。当合约到期日那天,持有股票期权的买方有权选择执行股票期权或是让股票期权作废。当然在合约到期日之前,持有股票期权的买方还可以卖出所持有的股票期权,卖出股票期权的卖方也可以买回期权平仓。(2)有几种股票期权两种。看涨期权又叫Call和看跌期权又叫Put(3)股票期权怎么交易股票期权的买卖单位是以一个合约为单位的(contract)。一个合约代表了100股股票的权利。如果我买了2个一个月后到期的股票ABC的看涨期权(Call)合约,表示一个月后股票期权到期日时,我有权买入200股ABC。如果股票期权价格为$1每股,买入1个合约的成本是:$1 x 100 = $100从交易方法来看,可以有4种方法:买入看涨期权(Long Call):看涨股票时,一般可以买入看涨期权买入看跌期权(Long Put):看跌股票时,一般可以买入看跌期权卖出看涨期权(Short Call):看跌股票时,可以卖出看涨期权。高风险卖出看跌期权(Short Put):看涨股票时,可以卖出看跌期权。高风险例:如有一只股票ABC 现在价格$10每股,我花$1每股买入了一个月后到期的$12的看涨期权(Call),一个月后ABC涨到了$15每股,我会选择执行我的看涨期权。这样我可以花$12每股买入ABC(至于谁会卖给我,我不用管),而ABC的市场价格已经是$15每股了,所以马上卖出ABC的话","listText":"美股期权交易基础最近很想把做股票期权(Option)的积累的认识,想法写下来,希望帮助那些想要进行Option交易的和刚刚入门的人。也希望有高手能够交流分享,指导。首先需要解决几个基本问题:(1)什么是股票期权 (Option)股票期权是一种建立在买方和卖方之间合约或叫约定。这种合约给了买方在特定价格(Strike Price)买入或卖出一只股票的权利。当然这种合约是有期限的。有可能是一个星期,也有可能是一个月,几个月或是一年两年。当合约到期日那天,持有股票期权的买方有权选择执行股票期权或是让股票期权作废。当然在合约到期日之前,持有股票期权的买方还可以卖出所持有的股票期权,卖出股票期权的卖方也可以买回期权平仓。(2)有几种股票期权两种。看涨期权又叫Call和看跌期权又叫Put(3)股票期权怎么交易股票期权的买卖单位是以一个合约为单位的(contract)。一个合约代表了100股股票的权利。如果我买了2个一个月后到期的股票ABC的看涨期权(Call)合约,表示一个月后股票期权到期日时,我有权买入200股ABC。如果股票期权价格为$1每股,买入1个合约的成本是:$1 x 100 = $100从交易方法来看,可以有4种方法:买入看涨期权(Long Call):看涨股票时,一般可以买入看涨期权买入看跌期权(Long Put):看跌股票时,一般可以买入看跌期权卖出看涨期权(Short Call):看跌股票时,可以卖出看涨期权。高风险卖出看跌期权(Short Put):看涨股票时,可以卖出看跌期权。高风险例:如有一只股票ABC 现在价格$10每股,我花$1每股买入了一个月后到期的$12的看涨期权(Call),一个月后ABC涨到了$15每股,我会选择执行我的看涨期权。这样我可以花$12每股买入ABC(至于谁会卖给我,我不用管),而ABC的市场价格已经是$15每股了,所以马上卖出ABC的话","text":"美股期权交易基础最近很想把做股票期权(Option)的积累的认识,想法写下来,希望帮助那些想要进行Option交易的和刚刚入门的人。也希望有高手能够交流分享,指导。首先需要解决几个基本问题:(1)什么是股票期权 (Option)股票期权是一种建立在买方和卖方之间合约或叫约定。这种合约给了买方在特定价格(Strike Price)买入或卖出一只股票的权利。当然这种合约是有期限的。有可能是一个星期,也有可能是一个月,几个月或是一年两年。当合约到期日那天,持有股票期权的买方有权选择执行股票期权或是让股票期权作废。当然在合约到期日之前,持有股票期权的买方还可以卖出所持有的股票期权,卖出股票期权的卖方也可以买回期权平仓。(2)有几种股票期权两种。看涨期权又叫Call和看跌期权又叫Put(3)股票期权怎么交易股票期权的买卖单位是以一个合约为单位的(contract)。一个合约代表了100股股票的权利。如果我买了2个一个月后到期的股票ABC的看涨期权(Call)合约,表示一个月后股票期权到期日时,我有权买入200股ABC。如果股票期权价格为$1每股,买入1个合约的成本是:$1 x 100 = $100从交易方法来看,可以有4种方法:买入看涨期权(Long Call):看涨股票时,一般可以买入看涨期权买入看跌期权(Long Put):看跌股票时,一般可以买入看跌期权卖出看涨期权(Short Call):看跌股票时,可以卖出看涨期权。高风险卖出看跌期权(Short Put):看涨股票时,可以卖出看跌期权。高风险例:如有一只股票ABC 现在价格$10每股,我花$1每股买入了一个月后到期的$12的看涨期权(Call),一个月后ABC涨到了$15每股,我会选择执行我的看涨期权。这样我可以花$12每股买入ABC(至于谁会卖给我,我不用管),而ABC的市场价格已经是$15每股了,所以马上卖出ABC的话","images":[{"img":"https://static.tigerbbs.com/2c1b9bf77aa1a8605d56b00a664b27d0","width":"1242","height":"2208"}],"top":1,"highlighted":2,"essential":1,"paper":2,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/395700180","isVote":1,"tweetType":1,"viewCount":0,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":2,"langContent":"CN","totalScore":0},"isVote":1,"tweetType":1,"viewCount":875,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":395495870,"gmtCreate":1607702428190,"gmtModify":1703849636241,"author":{"id":"3548930401820895","authorId":"3548930401820895","name":"爱喝普洱的小兔子","avatar":"https://static.tigerbbs.com/83de70ea332657d3bb5b922b18e5afad","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"idStr":"3548930401820895","authorIdStr":"3548930401820895"},"themes":[],"htmlText":"<a href=\"https://laohu8.com/S/PLTR\">$Palantir Technologies Inc.(PLTR)$</a>这跌不下去,怎么加仓","listText":"<a href=\"https://laohu8.com/S/PLTR\">$Palantir Technologies Inc.(PLTR)$</a>这跌不下去,怎么加仓","text":"$Palantir Technologies Inc.(PLTR)$这跌不下去,怎么加仓","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/395495870","isVote":1,"tweetType":1,"viewCount":542,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":392390739,"gmtCreate":1607357595821,"gmtModify":1703847419426,"author":{"id":"3548930401820895","authorId":"3548930401820895","name":"爱喝普洱的小兔子","avatar":"https://static.tigerbbs.com/83de70ea332657d3bb5b922b18e5afad","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"idStr":"3548930401820895","authorIdStr":"3548930401820895"},"themes":[],"htmlText":"这篇文章不错,转发给大家看看","listText":"这篇文章不错,转发给大家看看","text":"这篇文章不错,转发给大家看看","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/392390739","repostId":"396713296","repostType":1,"repost":{"id":396713296,"gmtCreate":1607318076115,"gmtModify":1703847026912,"author":{"id":"3496215943716304","authorId":"3496215943716304","name":"换汤不换药","avatar":"https://static.tigerbbs.com/7527881faee6e24547686baa58b87eea","crmLevel":1,"crmLevelSwitch":0,"followedFlag":false,"idStr":"3496215943716304","authorIdStr":"3496215943716304"},"themes":[],"title":"美股上市药企分析—Mersana Therapeutics","htmlText":"<a target=\"_blank\" href=\"https://laohu8.com/S/MRSN\">$Mersana Therapeutics Inc.(MRSN)$</a> 前言Mersana Therapeutics专注于开发抗体偶联药物(ADCs),其独创的高分子偶联技术,有望解决癌症患者大量未被满足的临床需求。01 基本面分析1.1 公司基本介绍 Mersana Therapeutics 成立于2002年,总部位于美国马萨诸塞州, 专注于为具有显著未满足需求的癌症患者提供抗体偶联药物(Antibody Drug Conjugates, ADCs)开发。 公司于2017年6月28日在纳斯达克上市,发行价15美元,上市时市值约为3.39 亿美元 。1.2 公司技术介绍 ADC目前已经成为全球抗体药物研发的热门方向,其中的代表产品,罗氏的Kadcyla(针对 HER2 靶点)在2019年实现了13.93亿瑞士法郎(约12.64亿美元)的收入,成为又一个年销量超过10亿美元的重磅药物。 A DC药物的设计思路是将抗体与细胞毒药物进行偶联,从而同时发挥抗体高特 异性与细胞毒性小分子的高毒性,利用抗体与抗原的高度靶向结合,将药物输送至肿瘤部位,释放细胞毒性小分子,使杀伤能力集中于肿瘤细胞,降低正常组织的毒副作用。ADC药物作用机制,资料来源:财通证券研究所 但传统ADC药物存在的问题是,小分子水溶性差而抗体水溶性好,且linker不稳定,容易造成脱靶,这必然带来蛋白聚集、毒副作用大的问题。 那么,Mersana是如何解决这个问题的呢? 对于传统的ADC药物,一旦释放出毒性小分子到靶细胞中,这些小分子药物通常能够穿 过细胞膜,进入并杀死临近的细胞,不管这些细胞是否癌变,这种效应被称为“旁观者效应”(bystander-killing)。 当旁观者细胞具有癌变性时,这","listText":"<a target=\"_blank\" href=\"https://laohu8.com/S/MRSN\">$Mersana Therapeutics Inc.(MRSN)$</a> 前言Mersana Therapeutics专注于开发抗体偶联药物(ADCs),其独创的高分子偶联技术,有望解决癌症患者大量未被满足的临床需求。01 基本面分析1.1 公司基本介绍 Mersana Therapeutics 成立于2002年,总部位于美国马萨诸塞州, 专注于为具有显著未满足需求的癌症患者提供抗体偶联药物(Antibody Drug Conjugates, ADCs)开发。 公司于2017年6月28日在纳斯达克上市,发行价15美元,上市时市值约为3.39 亿美元 。1.2 公司技术介绍 ADC目前已经成为全球抗体药物研发的热门方向,其中的代表产品,罗氏的Kadcyla(针对 HER2 靶点)在2019年实现了13.93亿瑞士法郎(约12.64亿美元)的收入,成为又一个年销量超过10亿美元的重磅药物。 A DC药物的设计思路是将抗体与细胞毒药物进行偶联,从而同时发挥抗体高特 异性与细胞毒性小分子的高毒性,利用抗体与抗原的高度靶向结合,将药物输送至肿瘤部位,释放细胞毒性小分子,使杀伤能力集中于肿瘤细胞,降低正常组织的毒副作用。ADC药物作用机制,资料来源:财通证券研究所 但传统ADC药物存在的问题是,小分子水溶性差而抗体水溶性好,且linker不稳定,容易造成脱靶,这必然带来蛋白聚集、毒副作用大的问题。 那么,Mersana是如何解决这个问题的呢? 对于传统的ADC药物,一旦释放出毒性小分子到靶细胞中,这些小分子药物通常能够穿 过细胞膜,进入并杀死临近的细胞,不管这些细胞是否癌变,这种效应被称为“旁观者效应”(bystander-killing)。 当旁观者细胞具有癌变性时,这","text":"$Mersana Therapeutics Inc.(MRSN)$ 前言Mersana Therapeutics专注于开发抗体偶联药物(ADCs),其独创的高分子偶联技术,有望解决癌症患者大量未被满足的临床需求。01 基本面分析1.1 公司基本介绍 Mersana Therapeutics 成立于2002年,总部位于美国马萨诸塞州, 专注于为具有显著未满足需求的癌症患者提供抗体偶联药物(Antibody Drug Conjugates, ADCs)开发。 公司于2017年6月28日在纳斯达克上市,发行价15美元,上市时市值约为3.39 亿美元 。1.2 公司技术介绍 ADC目前已经成为全球抗体药物研发的热门方向,其中的代表产品,罗氏的Kadcyla(针对 HER2 靶点)在2019年实现了13.93亿瑞士法郎(约12.64亿美元)的收入,成为又一个年销量超过10亿美元的重磅药物。 A DC药物的设计思路是将抗体与细胞毒药物进行偶联,从而同时发挥抗体高特 异性与细胞毒性小分子的高毒性,利用抗体与抗原的高度靶向结合,将药物输送至肿瘤部位,释放细胞毒性小分子,使杀伤能力集中于肿瘤细胞,降低正常组织的毒副作用。ADC药物作用机制,资料来源:财通证券研究所 但传统ADC药物存在的问题是,小分子水溶性差而抗体水溶性好,且linker不稳定,容易造成脱靶,这必然带来蛋白聚集、毒副作用大的问题。 那么,Mersana是如何解决这个问题的呢? 对于传统的ADC药物,一旦释放出毒性小分子到靶细胞中,这些小分子药物通常能够穿 过细胞膜,进入并杀死临近的细胞,不管这些细胞是否癌变,这种效应被称为“旁观者效应”(bystander-killing)。 当旁观者细胞具有癌变性时,这","images":[{"img":"https://static.tigerbbs.com/25312b48c0f2d7f25300b57514ae37af","width":"554","height":"155"},{"img":"https://static.tigerbbs.com/52a871033a22c3a3d45763cde824828f","width":"554","height":"135"},{"img":"https://static.tigerbbs.com/9c523c875db6364842918ee58d3ccccb","width":"554","height":"129"}],"top":1,"highlighted":2,"essential":2,"paper":2,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/396713296","isVote":1,"tweetType":1,"viewCount":0,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":11,"langContent":"CN","totalScore":0},"isVote":1,"tweetType":1,"viewCount":365,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":392057841,"gmtCreate":1607344504683,"gmtModify":1703847235298,"author":{"id":"3548930401820895","authorId":"3548930401820895","name":"爱喝普洱的小兔子","avatar":"https://static.tigerbbs.com/83de70ea332657d3bb5b922b18e5afad","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"idStr":"3548930401820895","authorIdStr":"3548930401820895"},"themes":[],"htmlText":"这篇文章不错,转发给大家看看","listText":"这篇文章不错,转发给大家看看","text":"这篇文章不错,转发给大家看看","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":1,"repostSize":0,"link":"https://laohu8.com/post/392057841","repostId":"398728437","repostType":1,"repost":{"id":398728437,"gmtCreate":1606970683424,"gmtModify":1716218869424,"author":{"id":"36984908995200","authorId":"36984908995200","name":"小虎活动","avatar":"https://static.tigerbbs.com/9e396d03155923b283948d2dec9191f8","crmLevel":1,"crmLevelSwitch":0,"followedFlag":false,"idStr":"36984908995200","authorIdStr":"36984908995200"},"themes":[],"title":"2020年老虎年度人物评选开始啦,即刻投出所爱!","htmlText":"一年一度的“老虎社区年度人物”评选又开始啦!谁将勇夺2020老虎社区年度人物,将由你的投票决定,快来为你喜欢的大V打榜(本次活动除了大V会获得礼物外,参与投票的虎友也有机会获得虎币,注意本次活动最多可以投三票。)2020年是资本市场市场跌宕起伏的一年,也是投资者乘风破浪的一年。老虎年度人物正是这样“一群人”,ta们不被定义,发现无限可能。 我们通过对所有用户的发帖量、帖子阅读数、回复点赞数、新增粉丝数等多个维度进行打分,筛选出了30位影响力用户提名。谁将获得年度人物?将由你来决定,即刻投出所爱! 以下为影响力用户排名(排名不分先后) @牛万最不懂snap,@投资信仰 ,@看懂趋势股,@看遍世界景赚足天下钱 ,@空军大队长,@SSally,@MidasMike,@我就三手茅台鸭,@阿文顽股 ,@StockCurry ,@牛唐 ,@蒋书杰_美股玩家 ,@美股队长8 ,@明亮蓝影 ,@springboot ,@Cedricly ,@阳光财经 ,@贝瑞研究 ,@价值投资为王 ,@柳下惠的气质 ,@甘灿荣_交易所讲师及资管 ,@Santi小汤 ,@程俊Dream ,@华尔街头狼 ,@安心睡大觉 ,@杨星榆 ,@期权量化策略 ,@投资小达人 ,@约翰 ,@大哥千万别站山上 【活动时间】 即日起-12月24日 【活动奖励】 老虎社区年度人物大奖前10名均可获得电动三宝股票(蔚来、小鹏、理想各1股) 本次入围的影响力用户均可获得台历一本,另外评论区点赞第一的用户也可获得台历 另外我们将选取给“最终票数第6名”投票的虎友们发放66虎币 【活动奖励说明】 我们将在25日公布获奖名单,并在公布获奖名单一周内为大家派发股票, 股票将于10个工作日内发放至您的综合账户持仓,您需要在15天选择领取,过期未领取,奖励将自动失效。 活动最终解释权归老虎社区所有。 欢迎各位大V转发本帖拉票,也欢迎各位虎友为","listText":"一年一度的“老虎社区年度人物”评选又开始啦!谁将勇夺2020老虎社区年度人物,将由你的投票决定,快来为你喜欢的大V打榜(本次活动除了大V会获得礼物外,参与投票的虎友也有机会获得虎币,注意本次活动最多可以投三票。)2020年是资本市场市场跌宕起伏的一年,也是投资者乘风破浪的一年。老虎年度人物正是这样“一群人”,ta们不被定义,发现无限可能。 我们通过对所有用户的发帖量、帖子阅读数、回复点赞数、新增粉丝数等多个维度进行打分,筛选出了30位影响力用户提名。谁将获得年度人物?将由你来决定,即刻投出所爱! 以下为影响力用户排名(排名不分先后) @牛万最不懂snap,@投资信仰 ,@看懂趋势股,@看遍世界景赚足天下钱 ,@空军大队长,@SSally,@MidasMike,@我就三手茅台鸭,@阿文顽股 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我们通过对所有用户的发帖量、帖子阅读数、回复点赞数、新增粉丝数等多个维度进行打分,筛选出了30位影响力用户提名。谁将获得年度人物?将由你来决定,即刻投出所爱! 以下为影响力用户排名(排名不分先后) @牛万最不懂snap,@投资信仰 ,@看懂趋势股,@看遍世界景赚足天下钱 ,@空军大队长,@SSally,@MidasMike,@我就三手茅台鸭,@阿文顽股 ,@StockCurry ,@牛唐 ,@蒋书杰_美股玩家 ,@美股队长8 ,@明亮蓝影 ,@springboot ,@Cedricly ,@阳光财经 ,@贝瑞研究 ,@价值投资为王 ,@柳下惠的气质 ,@甘灿荣_交易所讲师及资管 ,@Santi小汤 ,@程俊Dream ,@华尔街头狼 ,@安心睡大觉 ,@杨星榆 ,@期权量化策略 ,@投资小达人 ,@约翰 ,@大哥千万别站山上 【活动时间】 即日起-12月24日 【活动奖励】 老虎社区年度人物大奖前10名均可获得电动三宝股票(蔚来、小鹏、理想各1股) 本次入围的影响力用户均可获得台历一本,另外评论区点赞第一的用户也可获得台历 另外我们将选取给“最终票数第6名”投票的虎友们发放66虎币 【活动奖励说明】 我们将在25日公布获奖名单,并在公布获奖名单一周内为大家派发股票, 股票将于10个工作日内发放至您的综合账户持仓,您需要在15天选择领取,过期未领取,奖励将自动失效。 活动最终解释权归老虎社区所有。 欢迎各位大V转发本帖拉票,也欢迎各位虎友为","listText":"一年一度的“老虎社区年度人物”评选又开始啦!谁将勇夺2020老虎社区年度人物,将由你的投票决定,快来为你喜欢的大V打榜(本次活动除了大V会获得礼物外,参与投票的虎友也有机会获得虎币,注意本次活动最多可以投三票。)2020年是资本市场市场跌宕起伏的一年,也是投资者乘风破浪的一年。老虎年度人物正是这样“一群人”,ta们不被定义,发现无限可能。 我们通过对所有用户的发帖量、帖子阅读数、回复点赞数、新增粉丝数等多个维度进行打分,筛选出了30位影响力用户提名。谁将获得年度人物?将由你来决定,即刻投出所爱! 以下为影响力用户排名(排名不分先后) @牛万最不懂snap,@投资信仰 ,@看懂趋势股,@看遍世界景赚足天下钱 ,@空军大队长,@SSally,@MidasMike,@我就三手茅台鸭,@阿文顽股 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00:14","market":"us","language":"zh","title":"线上教育巨头Coursera来了!IPO定价每股33美元","url":"https://stock-news.laohu8.com/highlight/detail?id=1171962223","media":"新浪科技 ","summary":"4月1日消息,线上教育巨头Coursera今晚登陆美股,首发上市涨21.21%,报40美元,IPO定价为33美元。据悉,该公司通过IPO筹集了5.19亿美元,此次估值为43亿美元。其IPO定价为每股3","content":"<p>4月1日消息,线上教育巨头Coursera今晚登陆美股,首发上市涨21.21%,报40美元,IPO定价为33美元。</p><p><img src=\"https://static.tigerbbs.com/02b9c1d8ca315aee021355dfdcf3bbf9\" tg-width=\"662\" tg-height=\"418\"></p><p><b>据悉,该公司通过IPO筹集了5.19亿美元,此次估值为43亿美元。其IPO定价为每股33美元</b>,处于其目标区间30美元至33美元的上限。该公司此次发行1573万股股份。</p><p>Coursera的官网显示,这是一家总部位于加利福尼亚州的线上课程提供商,公司成立于2012年。该公司与200多所大学和公司达成合作,“为世界各地的个人和组织带来灵活、价格低廉、与工作相关的线上学习服务”。其课程包括指导性项目、专业证书,甚至是全面学位教育。</p><p>在上一财年中,Coursera的收入为2.935亿美元,同比增长59%。然而,净亏损也同比增加约2000万美元,至6680万美元。</p><p>此外,Coursera表示,该公司“在截至2020年12月31日的两年里,为学生增加了12000多个新学位,平均购课成本不到2000美元。”去年其注册用户总数增长了65%。</p><p><b>以下是关于Coursera的5件你需要了解的事情。</b></p><p><b>Coursera通过相对较低的成本吸引用户从而获得赢利</b></p><p>Coursera凭借其平台上大量的免费课程而被人们所熟知:在该公司约7700万用户中,只有360万人付费购买了课程或其他课程。但分析师表示,Coursera的商业模式允许该公司花费比竞争对手更少的费用来吸引那些付费用户。</p><p>该公司有三条主要的业务线,第一种是直接面向消费者,感兴趣的用户可以报名参加免费课程;也可以参与付费课程,包括两个小时的指导项目课程,价格9.99美元;以及需要3到9个月的学习才能获得的专业证书,每月收费39到99美元。</p><p>第二个业务线是其企业业务,企业、政府和其他机构付钱给Coursera,让他们提供员工可以用来提升技能或重新掌握技能的课程。Coursera表示,截至去年年底,有2,000多家公司向Coursera支付了这些服务的费用,其中包括25%的财富500强公司。</p><p>第三个是其学位项目,通过这一细分领域,该公司与大学合作,提供学士和硕士学位。在这些安排中,学院招收学生,教职员工教授课程,学校授予学位。但Coursera承担了大部分营销和技术工作,从而换取一定比例的学费收入。</p><p>贝伦伯格资本市场(Berenberg Capital Markets)负责教育技术的股票研究副总裁布雷特·诺布拉赫(Brett Knoblauch)说,“当你有了这样一个统一的平台,你就可以廉价地建立一个非常庞大的业务,推动学生选择你提供的各种课程。”</p><p>该公司自己的数据显示,2020年,Coursera约50%的学位学生之前是在该网站注册的,该公司超过30%的企业客户来自消费者平台。</p><p>该公司提交的S-1文件显示,在2020年底之前的两年里,该公司以每个学生2000美元的成本获得了1.2万名新学位学生。卢里表示,这个学生获取成本低于其他类似的平台。</p><p>随着平台的发展,该公司还有可能越来越多地受益于网络效应,即每增加一个客户,该平台就会变得对其他客户更有吸引力。诺布拉赫表示,每个新客户都创造了一个扩大公司内容库的机会,增加了该平台对其他客户的吸引力。他说道:“随着平台上学位数量、课程数量或专业数量的累计,这将为该公司创造更多的价值。”</p><p><img src=\"https://static.tigerbbs.com/7c7c31c667d5b499d549393b6221ab82\" tg-width=\"630\" tg-height=\"372\" referrerpolicy=\"no-referrer\"></p><p><b>Coursera在疫情期间新增数千万新用户</b></p><p>2020年之中,Coursera平台新增了大约3060万名新用户,高于2019年的920万人。教育研究和咨询公司EduVentures Research的首席分析师霍华德·卢里表示:“这是一个非常大的增幅。”</p><p>能够短时间内新增3000余万用户,当然很大程度上与疫情全球大流行有关。Coursera表示,在2020年3月下旬的高峰期,它的注册人数比平均水平高出了15倍。</p><p><b>该公司尚未实现盈利</b></p><p>去年Coursera亏损了6680万美元,比2019年的4670万美元有所上涨。该公司表示,预计在可预见的未来,随着课程提供、用户获取和营销努力的扩大,以及从事其他增长活动,其运营费用将继续增加。</p><p>卢里认为:“他们可能还需要一段时间才能盈利。”2020年,该公司的收入从2019年的1.844亿美元增长到了2.935亿美元。</p><p><b>线上学位教育对大学越来越有吸引力 但仍存在一定风险</b></p><p>在线上学位教育方面,公立和私立非营利性大学一直以来都表现得犹豫不决,因为这种教育方式往往与盈利性大学联系在一起,后者所提供的学位,在就业市场上往往价值不高,而且在接受教育时,盈利性大学的收费非常昂贵。</p><p>诺布拉赫表示:“大学在投资线上教育方面历来落后,他们犹豫不决的原因是担心这种教学方式会影响自己的声誉。大学最看重的就是自己的品牌,这是他们吸引学生的手段。”</p><p>Coursera表示,对营利性大学及其在线教育项目的审查可能会给他们的业务带来风险。该公司在其S-1报告中表示:“尽管我们没有向这些机构推销我们的解决方案,但这种负面的媒体关注可能会加剧人们对在线高等教育的怀疑,包括对我们的解决方案产生怀疑。”</p><p>但是诺布拉赫表示,公立和非营利性学院和大学正面临预算方面的挑战,这可能会推动它们通过线上学位教育获得收入。去年,许多大学失去了用于住房、餐饮、停车、体育和其他领域的资金。</p><p>虽然与Coursera这样的公司合作,提供线上学位教育有可能为大学带来更多的学费收入,但是这种做法也存在争议。批评人士担心,线上教育平台和大学之间的合同安排,即公司获得一定比例的学费收入,会抬高学生的入学成本。</p><p><b>Coursera将成为一家公益企业</b></p><p>Coursera将被合并为特拉华州的公益企业,这是一种法律实体,企业在服务股东利益的同时,也兼顾公共利益。</p><p>该公司也是一家经过认证的B-Corp,这意味着非营利性组织B-Lab已经评估了Coursera的商业实践,并确定它在为员工、社区和环境带来价值方面符合其标准。</p>","source":"sina_tech","collect":0,"html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" 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</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>4月1日消息,线上教育巨头Coursera今晚登陆美股,首发上市涨21.21%,报40美元,IPO定价为33美元。据悉,该公司通过IPO筹集了5.19亿美元,此次估值为43亿美元。其IPO定价为每股33美元,处于其目标区间30美元至33美元的上限。该公司此次发行1573万股股份。Coursera的官网显示,这是一家总部位于加利福尼亚州的线上课程提供商,公司成立于2012年。该公司与200多所大学和...</p>\n\n<a href=\"https://finance.sina.com.cn/tech/2021-03-31/doc-ikmyaawa2739379.shtml\">Web Link</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","type":0,"thumbnail":"https://static.tigerbbs.com/7c7c31c667d5b499d549393b6221ab82","relate_stocks":{"COUR":"Coursera, Inc."},"source_url":"https://finance.sina.com.cn/tech/2021-03-31/doc-ikmyaawa2739379.shtml","is_english":false,"share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","article_id":"1171962223","content_text":"4月1日消息,线上教育巨头Coursera今晚登陆美股,首发上市涨21.21%,报40美元,IPO定价为33美元。据悉,该公司通过IPO筹集了5.19亿美元,此次估值为43亿美元。其IPO定价为每股33美元,处于其目标区间30美元至33美元的上限。该公司此次发行1573万股股份。Coursera的官网显示,这是一家总部位于加利福尼亚州的线上课程提供商,公司成立于2012年。该公司与200多所大学和公司达成合作,“为世界各地的个人和组织带来灵活、价格低廉、与工作相关的线上学习服务”。其课程包括指导性项目、专业证书,甚至是全面学位教育。在上一财年中,Coursera的收入为2.935亿美元,同比增长59%。然而,净亏损也同比增加约2000万美元,至6680万美元。此外,Coursera表示,该公司“在截至2020年12月31日的两年里,为学生增加了12000多个新学位,平均购课成本不到2000美元。”去年其注册用户总数增长了65%。以下是关于Coursera的5件你需要了解的事情。Coursera通过相对较低的成本吸引用户从而获得赢利Coursera凭借其平台上大量的免费课程而被人们所熟知:在该公司约7700万用户中,只有360万人付费购买了课程或其他课程。但分析师表示,Coursera的商业模式允许该公司花费比竞争对手更少的费用来吸引那些付费用户。该公司有三条主要的业务线,第一种是直接面向消费者,感兴趣的用户可以报名参加免费课程;也可以参与付费课程,包括两个小时的指导项目课程,价格9.99美元;以及需要3到9个月的学习才能获得的专业证书,每月收费39到99美元。第二个业务线是其企业业务,企业、政府和其他机构付钱给Coursera,让他们提供员工可以用来提升技能或重新掌握技能的课程。Coursera表示,截至去年年底,有2,000多家公司向Coursera支付了这些服务的费用,其中包括25%的财富500强公司。第三个是其学位项目,通过这一细分领域,该公司与大学合作,提供学士和硕士学位。在这些安排中,学院招收学生,教职员工教授课程,学校授予学位。但Coursera承担了大部分营销和技术工作,从而换取一定比例的学费收入。贝伦伯格资本市场(Berenberg Capital Markets)负责教育技术的股票研究副总裁布雷特·诺布拉赫(Brett Knoblauch)说,“当你有了这样一个统一的平台,你就可以廉价地建立一个非常庞大的业务,推动学生选择你提供的各种课程。”该公司自己的数据显示,2020年,Coursera约50%的学位学生之前是在该网站注册的,该公司超过30%的企业客户来自消费者平台。该公司提交的S-1文件显示,在2020年底之前的两年里,该公司以每个学生2000美元的成本获得了1.2万名新学位学生。卢里表示,这个学生获取成本低于其他类似的平台。随着平台的发展,该公司还有可能越来越多地受益于网络效应,即每增加一个客户,该平台就会变得对其他客户更有吸引力。诺布拉赫表示,每个新客户都创造了一个扩大公司内容库的机会,增加了该平台对其他客户的吸引力。他说道:“随着平台上学位数量、课程数量或专业数量的累计,这将为该公司创造更多的价值。”Coursera在疫情期间新增数千万新用户2020年之中,Coursera平台新增了大约3060万名新用户,高于2019年的920万人。教育研究和咨询公司EduVentures Research的首席分析师霍华德·卢里表示:“这是一个非常大的增幅。”能够短时间内新增3000余万用户,当然很大程度上与疫情全球大流行有关。Coursera表示,在2020年3月下旬的高峰期,它的注册人数比平均水平高出了15倍。该公司尚未实现盈利去年Coursera亏损了6680万美元,比2019年的4670万美元有所上涨。该公司表示,预计在可预见的未来,随着课程提供、用户获取和营销努力的扩大,以及从事其他增长活动,其运营费用将继续增加。卢里认为:“他们可能还需要一段时间才能盈利。”2020年,该公司的收入从2019年的1.844亿美元增长到了2.935亿美元。线上学位教育对大学越来越有吸引力 但仍存在一定风险在线上学位教育方面,公立和私立非营利性大学一直以来都表现得犹豫不决,因为这种教育方式往往与盈利性大学联系在一起,后者所提供的学位,在就业市场上往往价值不高,而且在接受教育时,盈利性大学的收费非常昂贵。诺布拉赫表示:“大学在投资线上教育方面历来落后,他们犹豫不决的原因是担心这种教学方式会影响自己的声誉。大学最看重的就是自己的品牌,这是他们吸引学生的手段。”Coursera表示,对营利性大学及其在线教育项目的审查可能会给他们的业务带来风险。该公司在其S-1报告中表示:“尽管我们没有向这些机构推销我们的解决方案,但这种负面的媒体关注可能会加剧人们对在线高等教育的怀疑,包括对我们的解决方案产生怀疑。”但是诺布拉赫表示,公立和非营利性学院和大学正面临预算方面的挑战,这可能会推动它们通过线上学位教育获得收入。去年,许多大学失去了用于住房、餐饮、停车、体育和其他领域的资金。虽然与Coursera这样的公司合作,提供线上学位教育有可能为大学带来更多的学费收入,但是这种做法也存在争议。批评人士担心,线上教育平台和大学之间的合同安排,即公司获得一定比例的学费收入,会抬高学生的入学成本。Coursera将成为一家公益企业Coursera将被合并为特拉华州的公益企业,这是一种法律实体,企业在服务股东利益的同时,也兼顾公共利益。该公司也是一家经过认证的B-Corp,这意味着非营利性组织B-Lab已经评估了Coursera的商业实践,并确定它在为员工、社区和环境带来价值方面符合其标准。","news_type":1},"isVote":1,"tweetType":1,"viewCount":1088,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":369333979,"gmtCreate":1614003707491,"gmtModify":1614003707491,"author":{"id":"3548930401820895","authorId":"3548930401820895","name":"爱喝普洱的小兔子","avatar":"https://static.tigerbbs.com/83de70ea332657d3bb5b922b18e5afad","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3548930401820895","idStr":"3548930401820895"},"themes":[],"htmlText":"这篇文章不错,转发给大家看看","listText":"这篇文章不错,转发给大家看看","text":"这篇文章不错,转发给大家看看","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/369333979","repostId":"1199896052","repostType":4,"isVote":1,"tweetType":1,"viewCount":1013,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":318130340,"gmtCreate":1611845606180,"gmtModify":1703754928068,"author":{"id":"3548930401820895","authorId":"3548930401820895","name":"爱喝普洱的小兔子","avatar":"https://static.tigerbbs.com/83de70ea332657d3bb5b922b18e5afad","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3548930401820895","idStr":"3548930401820895"},"themes":[],"htmlText":"<a href=\"https://laohu8.com/S/SNDL\">$Sundial Growers Inc.(SNDL)$</a>为啥停牌了? ","listText":"<a href=\"https://laohu8.com/S/SNDL\">$Sundial Growers Inc.(SNDL)$</a>为啥停牌了? ","text":"$Sundial Growers Inc.(SNDL)$为啥停牌了?","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/318130340","isVote":1,"tweetType":1,"viewCount":1382,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":395703271,"gmtCreate":1607741727493,"gmtModify":1703849750588,"author":{"id":"3548930401820895","authorId":"3548930401820895","name":"爱喝普洱的小兔子","avatar":"https://static.tigerbbs.com/83de70ea332657d3bb5b922b18e5afad","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3548930401820895","idStr":"3548930401820895"},"themes":[],"htmlText":"这篇文章不错,转发给大家看看","listText":"这篇文章不错,转发给大家看看","text":"这篇文章不错,转发给大家看看","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/395703271","repostId":"395700180","repostType":1,"repost":{"id":395700180,"gmtCreate":1607740431440,"gmtModify":1728102290861,"author":{"id":"84591292386623","authorId":"84591292386623","name":"坡上之云阿龙","avatar":"https://static.tigerbbs.com/23192029e6cace475a85ecd015bbf903","crmLevel":6,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"84591292386623","idStr":"84591292386623"},"themes":[],"title":"财务自由:美股期权教学 老虎第一人","htmlText":"美股期权交易基础最近很想把做股票期权(Option)的积累的认识,想法写下来,希望帮助那些想要进行Option交易的和刚刚入门的人。也希望有高手能够交流分享,指导。首先需要解决几个基本问题:(1)什么是股票期权 (Option)股票期权是一种建立在买方和卖方之间合约或叫约定。这种合约给了买方在特定价格(Strike Price)买入或卖出一只股票的权利。当然这种合约是有期限的。有可能是一个星期,也有可能是一个月,几个月或是一年两年。当合约到期日那天,持有股票期权的买方有权选择执行股票期权或是让股票期权作废。当然在合约到期日之前,持有股票期权的买方还可以卖出所持有的股票期权,卖出股票期权的卖方也可以买回期权平仓。(2)有几种股票期权两种。看涨期权又叫Call和看跌期权又叫Put(3)股票期权怎么交易股票期权的买卖单位是以一个合约为单位的(contract)。一个合约代表了100股股票的权利。如果我买了2个一个月后到期的股票ABC的看涨期权(Call)合约,表示一个月后股票期权到期日时,我有权买入200股ABC。如果股票期权价格为$1每股,买入1个合约的成本是:$1 x 100 = $100从交易方法来看,可以有4种方法:买入看涨期权(Long Call):看涨股票时,一般可以买入看涨期权买入看跌期权(Long Put):看跌股票时,一般可以买入看跌期权卖出看涨期权(Short Call):看跌股票时,可以卖出看涨期权。高风险卖出看跌期权(Short Put):看涨股票时,可以卖出看跌期权。高风险例:如有一只股票ABC 现在价格$10每股,我花$1每股买入了一个月后到期的$12的看涨期权(Call),一个月后ABC涨到了$15每股,我会选择执行我的看涨期权。这样我可以花$12每股买入ABC(至于谁会卖给我,我不用管),而ABC的市场价格已经是$15每股了,所以马上卖出ABC的话","listText":"美股期权交易基础最近很想把做股票期权(Option)的积累的认识,想法写下来,希望帮助那些想要进行Option交易的和刚刚入门的人。也希望有高手能够交流分享,指导。首先需要解决几个基本问题:(1)什么是股票期权 (Option)股票期权是一种建立在买方和卖方之间合约或叫约定。这种合约给了买方在特定价格(Strike Price)买入或卖出一只股票的权利。当然这种合约是有期限的。有可能是一个星期,也有可能是一个月,几个月或是一年两年。当合约到期日那天,持有股票期权的买方有权选择执行股票期权或是让股票期权作废。当然在合约到期日之前,持有股票期权的买方还可以卖出所持有的股票期权,卖出股票期权的卖方也可以买回期权平仓。(2)有几种股票期权两种。看涨期权又叫Call和看跌期权又叫Put(3)股票期权怎么交易股票期权的买卖单位是以一个合约为单位的(contract)。一个合约代表了100股股票的权利。如果我买了2个一个月后到期的股票ABC的看涨期权(Call)合约,表示一个月后股票期权到期日时,我有权买入200股ABC。如果股票期权价格为$1每股,买入1个合约的成本是:$1 x 100 = $100从交易方法来看,可以有4种方法:买入看涨期权(Long Call):看涨股票时,一般可以买入看涨期权买入看跌期权(Long Put):看跌股票时,一般可以买入看跌期权卖出看涨期权(Short Call):看跌股票时,可以卖出看涨期权。高风险卖出看跌期权(Short Put):看涨股票时,可以卖出看跌期权。高风险例:如有一只股票ABC 现在价格$10每股,我花$1每股买入了一个月后到期的$12的看涨期权(Call),一个月后ABC涨到了$15每股,我会选择执行我的看涨期权。这样我可以花$12每股买入ABC(至于谁会卖给我,我不用管),而ABC的市场价格已经是$15每股了,所以马上卖出ABC的话","text":"美股期权交易基础最近很想把做股票期权(Option)的积累的认识,想法写下来,希望帮助那些想要进行Option交易的和刚刚入门的人。也希望有高手能够交流分享,指导。首先需要解决几个基本问题:(1)什么是股票期权 (Option)股票期权是一种建立在买方和卖方之间合约或叫约定。这种合约给了买方在特定价格(Strike Price)买入或卖出一只股票的权利。当然这种合约是有期限的。有可能是一个星期,也有可能是一个月,几个月或是一年两年。当合约到期日那天,持有股票期权的买方有权选择执行股票期权或是让股票期权作废。当然在合约到期日之前,持有股票期权的买方还可以卖出所持有的股票期权,卖出股票期权的卖方也可以买回期权平仓。(2)有几种股票期权两种。看涨期权又叫Call和看跌期权又叫Put(3)股票期权怎么交易股票期权的买卖单位是以一个合约为单位的(contract)。一个合约代表了100股股票的权利。如果我买了2个一个月后到期的股票ABC的看涨期权(Call)合约,表示一个月后股票期权到期日时,我有权买入200股ABC。如果股票期权价格为$1每股,买入1个合约的成本是:$1 x 100 = $100从交易方法来看,可以有4种方法:买入看涨期权(Long Call):看涨股票时,一般可以买入看涨期权买入看跌期权(Long Put):看跌股票时,一般可以买入看跌期权卖出看涨期权(Short Call):看跌股票时,可以卖出看涨期权。高风险卖出看跌期权(Short Put):看涨股票时,可以卖出看跌期权。高风险例:如有一只股票ABC 现在价格$10每股,我花$1每股买入了一个月后到期的$12的看涨期权(Call),一个月后ABC涨到了$15每股,我会选择执行我的看涨期权。这样我可以花$12每股买入ABC(至于谁会卖给我,我不用管),而ABC的市场价格已经是$15每股了,所以马上卖出ABC的话","images":[{"img":"https://static.tigerbbs.com/2c1b9bf77aa1a8605d56b00a664b27d0","width":"1242","height":"2208"}],"top":1,"highlighted":2,"essential":1,"paper":2,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/395700180","isVote":1,"tweetType":1,"viewCount":0,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":2,"langContent":"CN","totalScore":0},"isVote":1,"tweetType":1,"viewCount":1234,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":395709445,"gmtCreate":1607741224987,"gmtModify":1703849749057,"author":{"id":"3548930401820895","authorId":"3548930401820895","name":"爱喝普洱的小兔子","avatar":"https://static.tigerbbs.com/83de70ea332657d3bb5b922b18e5afad","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3548930401820895","idStr":"3548930401820895"},"themes":[],"htmlText":"这篇文章不错,转发给大家看看","listText":"这篇文章不错,转发给大家看看","text":"这篇文章不错,转发给大家看看","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/395709445","repostId":"395700180","repostType":1,"repost":{"id":395700180,"gmtCreate":1607740431440,"gmtModify":1728102290861,"author":{"id":"84591292386623","authorId":"84591292386623","name":"坡上之云阿龙","avatar":"https://static.tigerbbs.com/23192029e6cace475a85ecd015bbf903","crmLevel":6,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"84591292386623","idStr":"84591292386623"},"themes":[],"title":"财务自由:美股期权教学 老虎第一人","htmlText":"美股期权交易基础最近很想把做股票期权(Option)的积累的认识,想法写下来,希望帮助那些想要进行Option交易的和刚刚入门的人。也希望有高手能够交流分享,指导。首先需要解决几个基本问题:(1)什么是股票期权 (Option)股票期权是一种建立在买方和卖方之间合约或叫约定。这种合约给了买方在特定价格(Strike Price)买入或卖出一只股票的权利。当然这种合约是有期限的。有可能是一个星期,也有可能是一个月,几个月或是一年两年。当合约到期日那天,持有股票期权的买方有权选择执行股票期权或是让股票期权作废。当然在合约到期日之前,持有股票期权的买方还可以卖出所持有的股票期权,卖出股票期权的卖方也可以买回期权平仓。(2)有几种股票期权两种。看涨期权又叫Call和看跌期权又叫Put(3)股票期权怎么交易股票期权的买卖单位是以一个合约为单位的(contract)。一个合约代表了100股股票的权利。如果我买了2个一个月后到期的股票ABC的看涨期权(Call)合约,表示一个月后股票期权到期日时,我有权买入200股ABC。如果股票期权价格为$1每股,买入1个合约的成本是:$1 x 100 = $100从交易方法来看,可以有4种方法:买入看涨期权(Long Call):看涨股票时,一般可以买入看涨期权买入看跌期权(Long Put):看跌股票时,一般可以买入看跌期权卖出看涨期权(Short Call):看跌股票时,可以卖出看涨期权。高风险卖出看跌期权(Short Put):看涨股票时,可以卖出看跌期权。高风险例:如有一只股票ABC 现在价格$10每股,我花$1每股买入了一个月后到期的$12的看涨期权(Call),一个月后ABC涨到了$15每股,我会选择执行我的看涨期权。这样我可以花$12每股买入ABC(至于谁会卖给我,我不用管),而ABC的市场价格已经是$15每股了,所以马上卖出ABC的话","listText":"美股期权交易基础最近很想把做股票期权(Option)的积累的认识,想法写下来,希望帮助那些想要进行Option交易的和刚刚入门的人。也希望有高手能够交流分享,指导。首先需要解决几个基本问题:(1)什么是股票期权 (Option)股票期权是一种建立在买方和卖方之间合约或叫约定。这种合约给了买方在特定价格(Strike Price)买入或卖出一只股票的权利。当然这种合约是有期限的。有可能是一个星期,也有可能是一个月,几个月或是一年两年。当合约到期日那天,持有股票期权的买方有权选择执行股票期权或是让股票期权作废。当然在合约到期日之前,持有股票期权的买方还可以卖出所持有的股票期权,卖出股票期权的卖方也可以买回期权平仓。(2)有几种股票期权两种。看涨期权又叫Call和看跌期权又叫Put(3)股票期权怎么交易股票期权的买卖单位是以一个合约为单位的(contract)。一个合约代表了100股股票的权利。如果我买了2个一个月后到期的股票ABC的看涨期权(Call)合约,表示一个月后股票期权到期日时,我有权买入200股ABC。如果股票期权价格为$1每股,买入1个合约的成本是:$1 x 100 = $100从交易方法来看,可以有4种方法:买入看涨期权(Long Call):看涨股票时,一般可以买入看涨期权买入看跌期权(Long Put):看跌股票时,一般可以买入看跌期权卖出看涨期权(Short Call):看跌股票时,可以卖出看涨期权。高风险卖出看跌期权(Short Put):看涨股票时,可以卖出看跌期权。高风险例:如有一只股票ABC 现在价格$10每股,我花$1每股买入了一个月后到期的$12的看涨期权(Call),一个月后ABC涨到了$15每股,我会选择执行我的看涨期权。这样我可以花$12每股买入ABC(至于谁会卖给我,我不用管),而ABC的市场价格已经是$15每股了,所以马上卖出ABC的话","text":"美股期权交易基础最近很想把做股票期权(Option)的积累的认识,想法写下来,希望帮助那些想要进行Option交易的和刚刚入门的人。也希望有高手能够交流分享,指导。首先需要解决几个基本问题:(1)什么是股票期权 (Option)股票期权是一种建立在买方和卖方之间合约或叫约定。这种合约给了买方在特定价格(Strike Price)买入或卖出一只股票的权利。当然这种合约是有期限的。有可能是一个星期,也有可能是一个月,几个月或是一年两年。当合约到期日那天,持有股票期权的买方有权选择执行股票期权或是让股票期权作废。当然在合约到期日之前,持有股票期权的买方还可以卖出所持有的股票期权,卖出股票期权的卖方也可以买回期权平仓。(2)有几种股票期权两种。看涨期权又叫Call和看跌期权又叫Put(3)股票期权怎么交易股票期权的买卖单位是以一个合约为单位的(contract)。一个合约代表了100股股票的权利。如果我买了2个一个月后到期的股票ABC的看涨期权(Call)合约,表示一个月后股票期权到期日时,我有权买入200股ABC。如果股票期权价格为$1每股,买入1个合约的成本是:$1 x 100 = $100从交易方法来看,可以有4种方法:买入看涨期权(Long Call):看涨股票时,一般可以买入看涨期权买入看跌期权(Long Put):看跌股票时,一般可以买入看跌期权卖出看涨期权(Short Call):看跌股票时,可以卖出看涨期权。高风险卖出看跌期权(Short Put):看涨股票时,可以卖出看跌期权。高风险例:如有一只股票ABC 现在价格$10每股,我花$1每股买入了一个月后到期的$12的看涨期权(Call),一个月后ABC涨到了$15每股,我会选择执行我的看涨期权。这样我可以花$12每股买入ABC(至于谁会卖给我,我不用管),而ABC的市场价格已经是$15每股了,所以马上卖出ABC的话","images":[{"img":"https://static.tigerbbs.com/2c1b9bf77aa1a8605d56b00a664b27d0","width":"1242","height":"2208"}],"top":1,"highlighted":2,"essential":1,"paper":2,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/395700180","isVote":1,"tweetType":1,"viewCount":0,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":2,"langContent":"CN","totalScore":0},"isVote":1,"tweetType":1,"viewCount":875,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":395495870,"gmtCreate":1607702428190,"gmtModify":1703849636241,"author":{"id":"3548930401820895","authorId":"3548930401820895","name":"爱喝普洱的小兔子","avatar":"https://static.tigerbbs.com/83de70ea332657d3bb5b922b18e5afad","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3548930401820895","idStr":"3548930401820895"},"themes":[],"htmlText":"<a href=\"https://laohu8.com/S/PLTR\">$Palantir Technologies Inc.(PLTR)$</a>这跌不下去,怎么加仓","listText":"<a href=\"https://laohu8.com/S/PLTR\">$Palantir Technologies Inc.(PLTR)$</a>这跌不下去,怎么加仓","text":"$Palantir Technologies Inc.(PLTR)$这跌不下去,怎么加仓","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/395495870","isVote":1,"tweetType":1,"viewCount":542,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0},{"id":392390739,"gmtCreate":1607357595821,"gmtModify":1703847419426,"author":{"id":"3548930401820895","authorId":"3548930401820895","name":"爱喝普洱的小兔子","avatar":"https://static.tigerbbs.com/83de70ea332657d3bb5b922b18e5afad","crmLevel":2,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3548930401820895","idStr":"3548930401820895"},"themes":[],"htmlText":"这篇文章不错,转发给大家看看","listText":"这篇文章不错,转发给大家看看","text":"这篇文章不错,转发给大家看看","images":[],"top":1,"highlighted":1,"essential":1,"paper":1,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/392390739","repostId":"396713296","repostType":1,"repost":{"id":396713296,"gmtCreate":1607318076115,"gmtModify":1703847026912,"author":{"id":"3496215943716304","authorId":"3496215943716304","name":"换汤不换药","avatar":"https://static.tigerbbs.com/7527881faee6e24547686baa58b87eea","crmLevel":1,"crmLevelSwitch":0,"followedFlag":false,"authorIdStr":"3496215943716304","idStr":"3496215943716304"},"themes":[],"title":"美股上市药企分析—Mersana Therapeutics","htmlText":"<a target=\"_blank\" href=\"https://laohu8.com/S/MRSN\">$Mersana Therapeutics Inc.(MRSN)$</a> 前言Mersana Therapeutics专注于开发抗体偶联药物(ADCs),其独创的高分子偶联技术,有望解决癌症患者大量未被满足的临床需求。01 基本面分析1.1 公司基本介绍 Mersana Therapeutics 成立于2002年,总部位于美国马萨诸塞州, 专注于为具有显著未满足需求的癌症患者提供抗体偶联药物(Antibody Drug Conjugates, ADCs)开发。 公司于2017年6月28日在纳斯达克上市,发行价15美元,上市时市值约为3.39 亿美元 。1.2 公司技术介绍 ADC目前已经成为全球抗体药物研发的热门方向,其中的代表产品,罗氏的Kadcyla(针对 HER2 靶点)在2019年实现了13.93亿瑞士法郎(约12.64亿美元)的收入,成为又一个年销量超过10亿美元的重磅药物。 A DC药物的设计思路是将抗体与细胞毒药物进行偶联,从而同时发挥抗体高特 异性与细胞毒性小分子的高毒性,利用抗体与抗原的高度靶向结合,将药物输送至肿瘤部位,释放细胞毒性小分子,使杀伤能力集中于肿瘤细胞,降低正常组织的毒副作用。ADC药物作用机制,资料来源:财通证券研究所 但传统ADC药物存在的问题是,小分子水溶性差而抗体水溶性好,且linker不稳定,容易造成脱靶,这必然带来蛋白聚集、毒副作用大的问题。 那么,Mersana是如何解决这个问题的呢? 对于传统的ADC药物,一旦释放出毒性小分子到靶细胞中,这些小分子药物通常能够穿 过细胞膜,进入并杀死临近的细胞,不管这些细胞是否癌变,这种效应被称为“旁观者效应”(bystander-killing)。 当旁观者细胞具有癌变性时,这","listText":"<a target=\"_blank\" href=\"https://laohu8.com/S/MRSN\">$Mersana Therapeutics Inc.(MRSN)$</a> 前言Mersana Therapeutics专注于开发抗体偶联药物(ADCs),其独创的高分子偶联技术,有望解决癌症患者大量未被满足的临床需求。01 基本面分析1.1 公司基本介绍 Mersana Therapeutics 成立于2002年,总部位于美国马萨诸塞州, 专注于为具有显著未满足需求的癌症患者提供抗体偶联药物(Antibody Drug Conjugates, ADCs)开发。 公司于2017年6月28日在纳斯达克上市,发行价15美元,上市时市值约为3.39 亿美元 。1.2 公司技术介绍 ADC目前已经成为全球抗体药物研发的热门方向,其中的代表产品,罗氏的Kadcyla(针对 HER2 靶点)在2019年实现了13.93亿瑞士法郎(约12.64亿美元)的收入,成为又一个年销量超过10亿美元的重磅药物。 A DC药物的设计思路是将抗体与细胞毒药物进行偶联,从而同时发挥抗体高特 异性与细胞毒性小分子的高毒性,利用抗体与抗原的高度靶向结合,将药物输送至肿瘤部位,释放细胞毒性小分子,使杀伤能力集中于肿瘤细胞,降低正常组织的毒副作用。ADC药物作用机制,资料来源:财通证券研究所 但传统ADC药物存在的问题是,小分子水溶性差而抗体水溶性好,且linker不稳定,容易造成脱靶,这必然带来蛋白聚集、毒副作用大的问题。 那么,Mersana是如何解决这个问题的呢? 对于传统的ADC药物,一旦释放出毒性小分子到靶细胞中,这些小分子药物通常能够穿 过细胞膜,进入并杀死临近的细胞,不管这些细胞是否癌变,这种效应被称为“旁观者效应”(bystander-killing)。 当旁观者细胞具有癌变性时,这","text":"$Mersana Therapeutics Inc.(MRSN)$ 前言Mersana Therapeutics专注于开发抗体偶联药物(ADCs),其独创的高分子偶联技术,有望解决癌症患者大量未被满足的临床需求。01 基本面分析1.1 公司基本介绍 Mersana Therapeutics 成立于2002年,总部位于美国马萨诸塞州, 专注于为具有显著未满足需求的癌症患者提供抗体偶联药物(Antibody Drug Conjugates, ADCs)开发。 公司于2017年6月28日在纳斯达克上市,发行价15美元,上市时市值约为3.39 亿美元 。1.2 公司技术介绍 ADC目前已经成为全球抗体药物研发的热门方向,其中的代表产品,罗氏的Kadcyla(针对 HER2 靶点)在2019年实现了13.93亿瑞士法郎(约12.64亿美元)的收入,成为又一个年销量超过10亿美元的重磅药物。 A DC药物的设计思路是将抗体与细胞毒药物进行偶联,从而同时发挥抗体高特 异性与细胞毒性小分子的高毒性,利用抗体与抗原的高度靶向结合,将药物输送至肿瘤部位,释放细胞毒性小分子,使杀伤能力集中于肿瘤细胞,降低正常组织的毒副作用。ADC药物作用机制,资料来源:财通证券研究所 但传统ADC药物存在的问题是,小分子水溶性差而抗体水溶性好,且linker不稳定,容易造成脱靶,这必然带来蛋白聚集、毒副作用大的问题。 那么,Mersana是如何解决这个问题的呢? 对于传统的ADC药物,一旦释放出毒性小分子到靶细胞中,这些小分子药物通常能够穿 过细胞膜,进入并杀死临近的细胞,不管这些细胞是否癌变,这种效应被称为“旁观者效应”(bystander-killing)。 当旁观者细胞具有癌变性时,这","images":[{"img":"https://static.tigerbbs.com/25312b48c0f2d7f25300b57514ae37af","width":"554","height":"155"},{"img":"https://static.tigerbbs.com/52a871033a22c3a3d45763cde824828f","width":"554","height":"135"},{"img":"https://static.tigerbbs.com/9c523c875db6364842918ee58d3ccccb","width":"554","height":"129"}],"top":1,"highlighted":2,"essential":2,"paper":2,"likeSize":0,"commentSize":0,"repostSize":0,"link":"https://laohu8.com/post/396713296","isVote":1,"tweetType":1,"viewCount":0,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":11,"langContent":"CN","totalScore":0},"isVote":1,"tweetType":1,"viewCount":365,"authorTweetTopStatus":1,"verified":2,"comments":[],"imageCount":0,"langContent":"CN","totalScore":0}],"lives":[]}