$艾吉纳斯公司(AGEN)$$安帝君斯(AGEN)$ MSS CRC取得的一点点小突破,下一代CTLA-4呼之欲出Study HighlightsA total of 41 evaluable patients with metastatic MSS CRC received either 1 or 2 mg/kg botensilimab Q6W, and 3 mg/kg balstilimab Q2W. Patients were heavily pre-treated, with a median of 4 prior lines of therapy, and 34% had received prior immunotherapy. The botensilimab/balstilimab combination produced superior responses and strong durability, relative to what has been reported in separate trials for standard of care and other combinations currently in development.Objective responses:24% overall response rate73% disease control rate (partial response + stable disease)50% objective responses with greater than 50% tumor reductionDurability:80% objective responses ongoing at data cu