退货！福泰制药终止肝病基因疗法合作

药事纵横03-01

声明：因水平有限，错误不可避免，或有些信息非最及时，欢迎留言指出。本文仅作医疗健康相关药物介绍，非治疗方案推荐（若涉及）;本文不构成任何投资建议。Vertex Pharmaceuticals于2025年2月27日宣布终止与Verve Therapeutics的肝病基因编辑合作，将项目权利归还给Verve。该合作始于2022年，原计划开发针对未公开肝病的体内基因编辑疗法，Vertex支付了2500...

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Pharmaceuticals于2025年2月27日宣布终止与Verve Therapeutics的肝病基因编辑合作，将项目权利归还给Verve。该合作始于2022年，原计划开发针对未公开肝病的体内基因编辑疗法，Vertex支付了2500...</p>\n\n<a href=\"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250302060503abe37cb8&s=b\">网页链接</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4588","symbol_name":"碎股","start_time":0,"source_url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250302060503abe37cb8&s=b","article_id":"2516561294","we_media_id":null,"thumbnails":[],"rights":{"source":"tencent","url":"http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN20250302060503abe37cb8&s=b","rn_cache_url":null,"customStyle":"body{padding-top:10px;}#news_title{font-weight:bold;#titleStyle#;}#news_description span{font-size:12px;#descriptionStyle#;}.footer-note{#statement#}","selectors":".mod-LoadTzbdNews, body","filters":".relate-stock, .hot-list, .recom-box, 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Futai Pharmaceuticals terminates cooperation in gene therapy for liver disease","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"VRTX":1},"content_text":"声明：因水平有限，错误不可避免，或有些信息非最及时，欢迎留言指出。本文仅作医疗健康相关药物介绍，非治疗方案推荐（若涉及）;本文不构成任何投资建议。Vertex Pharmaceuticals于2025年2月27日宣布终止与Verve Therapeutics的肝病基因编辑合作，将项目权利归还给Verve。该合作始于2022年，原计划开发针对未公开肝病的体内基因编辑疗法，Vertex支付了2500万美元首付款及3500万美元股权投资，2024年Verve从中获得1190万美元收入。终止原因为Vertex“开发组合优先级调整”，这一决定给Verve的基因编辑管线带来更大压力。Verve的核心项目VERVE-102（靶向PCSK9基因降低胆固醇）正在推进Heart-2 1b期试验，针对杂合子家族性高胆固醇血症（HeFH）或早发冠心病患者。目前安全性数据良好，无严重不良事件，首批初步数据预计2025年Q2公布，最终数据将于2025年下半年发布。分析师预测其LDL-C降低效果或与诺华的Leqvio（40%-50%降幅）相当。此外，Verve计划2025年底前启动VERVE-102的II期临床试验，并探索与PD-1抑制剂联用潜力。Verve核心项目尽管失去Vertex支持，Verve与礼来（Lilly）的合作仍是关键。2023年双方达成超6亿美元协议，覆盖VERVE-102、VERVE-101（曾因肝损伤风险暂停，尚未恢复）、VERVE-201（靶向ANGPTL3治疗心血管疾病）及VERVE-301（降低脂蛋白a水平）等项目。礼来拥有VERVE-102完成I期后的合作选择权，决定将于2025年下半年揭晓。行业寒冬持续，Spotlight Therapeutics、Tome Biosciences等基因编辑公司接连关闭或倒闭，Verve的表现成为行业缩影。未来，平衡研发风险与商业化进程仍是所有基因编辑公司面临的挑战。参考资料：https://www.biospace.com/business/vertex-severs-liver-gene-therapies-partnership-with-verve","kind":"news","is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"-1","news_tag":"corporation","news_rank":0,"symbols":[],"gpt_button":1,"code":"91000000","status":"200"},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"deviceId":"web-server-community-laohu8-v3","version":"4.33.2","shortVersion":"4.33.2","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2516561294"}