默沙东(MRK.US)口服HIV疗法达两项关键3期试验主要终点

智通财经2024-12-20

智通财经APP获悉，默沙东(MRK.US)今日宣布两项关键性3期试验MK-8591A-051与MK-8591A-052达成主要终点。与对照抗病毒疗法(ART)相比，所开发的每日一次两药单片联合方案 doravirine/islatravir(DOR/ISL)在治疗已实现病毒学抑制的HIV-1感染成人患者时显示出非劣效性。默沙东计划在未来的科学会议上公布这些试验的详细结果，并将相关数据提交监管机构。

Doravirine是由默沙东开发的一种每日一次的口服创新非核苷逆转录酶抑制剂。它通过与HIV-1病毒的逆转录酶结合，防止HIV-1病毒将RNA转化为DNA，从而阻断HIV-1病毒复制。它已在美国获批用于治疗未接受过抗病毒疗法的成年HIV-1感染患者。

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