默沙东(MRK.US)HIF-2α抑制剂在华获批上市

智通财经11-21 21:12

智通财经APP获悉，11月21日，国家药监局网站显示，默沙东(MRK.US)的Belzutifan片(贝组替凡片)获批上市，适应症为von Hippel-Lindau(VHL)病相关肾细胞癌(RCC)、中枢神经系统(CNS)血管母细胞瘤或胰腺神经内分泌肿瘤(pNET)。

VHL是一种罕见的遗传性疾病，每3.6万人中就有1人患病。VHL患者不仅有罹患良性血管肿瘤的风险，也有罹患某些癌症的风险，包括肾细胞癌。

Belzutifan是一款小分子缺氧诱导因子2α(HIF-2α)抑制剂，可以减少与细胞增殖、血管生成和肿瘤生长相关的HIF-2α靶基因的转录和表达。

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