“减肥神药”引发肌肉流失再生元制药等生物技术公司研发新疗法

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智通财经APP获悉，随着市场对诺和诺德(NVO.US)旗下Wegovy和礼来(LLY.US)旗下Zepbound这类减肥药的需求激增，人们对这类药物可能带来的肌肉质量下降这一重大风险的担忧也有所加剧。越来越多的生物技术公司正在竞相解决这个问题。据悉，Wegovy和Zepbound等GLP-1类药物在减重方面拥有显著的效果，但这种减重很大程度上减的是肌肉量。当减少卡路里的摄入时，不仅脂肪会减少，肌肉...

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href=http://gu.qq.com/resources/shy/news/detail-v2/index.html#/?id=nesSN2024101414430495a5ffd0&s=b><strong>智通财经网</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>智通财经APP获悉，随着市场对诺和诺德(NVO.US)旗下Wegovy和礼来(LLY.US)旗下Zepbound这类减肥药的需求激增，人们对这类药物可能带来的肌肉质量下降这一重大风险的担忧也有所加剧。越来越多的生物技术公司正在竞相解决这个问题。据悉，Wegovy和Zepbound等GLP-1类药物在减重方面拥有显著的效果，但这种减重很大程度上减的是肌肉量。当减少卡路里的摄入时，不仅脂肪会减少，肌肉...</p>\n\n<a 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treatments","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"REGN":0.9,"MMAT":0.66},"content_text":"智通财经APP获悉，随着市场对诺和诺德(NVO.US)旗下Wegovy和礼来(LLY.US)旗下Zepbound这类减肥药的需求激增，人们对这类药物可能带来的肌肉质量下降这一重大风险的担忧也有所加剧。越来越多的生物技术公司正在竞相解决这个问题。据悉，Wegovy和Zepbound等GLP-1类药物在减重方面拥有显著的效果，但这种减重很大程度上减的是肌肉量。当减少卡路里的摄入时，不仅脂肪会减少，肌肉也会减少。尽管这种情形属于意料之中，但一些专家担心这会导致受伤的风险增加，尤其是老年人。另一个担忧是，肌肉减少可能会减慢患者的新陈代谢，导致体重反弹，至于体重反弹后是否会导致肌肉量相应程度的增加目前还不完全清楚。再生元制药(REGN.US)首席科学官George Yanopoulos表示，GLP-1类药物“可能会导致身体成分的连续变化，从长远来看弊大于利”。根据George Yanopoulos的说法，接受GLP-1类药物治疗的患者往往在一年内就有高达40%的体重减轻源自于肌肉流失，这不仅可能导致体脂比例上升，更重要的是，这种长期的身体改变可能引发各种健康问题。为了更好地应对这一问题，再生元制药展开了新的药物研发，目标是减少减肥药导致的肌肉流失。George Yanopoulos提到，该公司正在测试一种名为trevogrumab的药物，该药物旨在阻断抑制肌肉生长的激素。再生元制药并不是唯一一家研发肌生成抑制素靶向药物的制药公司。2023年，礼来收购了私营生物制药公司Versanis Bio，后者的主要资产是bimagrumab。这是一款靶向ActRII的在研单克隆抗体。在一项为期48周的临床II期试验中，在患有2型糖尿病的超重或肥胖患者中，与安慰剂组相比，bimagrumab能够造成患者约22%脂肪含量的损失，并增加4.5%的无脂体重。与此同时，Biohaven(BHVN.US)的肌生成抑制素靶向药物taldefgrobep alfa已经显示出与GLP-1类药物联合使用时增加肌肉的积极临床前数据。该公司在8月表示，将在2024年下半年开始针对肥胖患者的taldefgrobep alfa中期试验。Scholar Rock(SRRK.US)在上个月完成了其肌生成抑制素靶向药物apitegromab的2期临床试验。这项名为EMBRAZE的研究旨在展示其在使用GLP-1类药物治疗肥胖的个体中保留瘦肌肉量的概念验证。其中公司的相关药物则提供了不同的机制。Keros Therapeutics(KROS.US)肥胖候选药物KER-065旨在通过诱导身体的能量消耗来增加骨骼肌和减少脂肪量，目前处于1期开发阶段。上个月刚上市的BioAge Labs(BIOA.US)已经开始了一项中期研究，以测试其主要候选药物azelaprag与礼来旗下tirzepatide联合治疗老年肥胖患者。据悉，前期的临床前研究及1期临床研究显示，azelaprag可改善代谢和肌肉功能，显著增加接受GLP-1类药物治疗的患者的体重减轻并改善身体成分和肌肉功能。此外，Veru(VERU.US)旗下口服疗法enobosarm目前正处于2期试验阶段，旨在评估enobosarm在接受GLP-1治疗的患者的减脂效果和防止肌肉流失方面的潜力。","kind":null,"is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; 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“减肥神药”引发肌肉流失 再生元制药等生物技术公司研发新疗法

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“减肥神药”引发肌肉流失再生元制药等生物技术公司研发新疗法