礼来创历史新高！“减肥神药”几乎 “预防”糖尿病，但是.....

华尔街见闻08-21

不仅可以减肥，还能“预防”糖尿病，礼来减肥药势不可挡，股价隔夜涨超3%逼近历史高点，8月份以来已大涨15%。礼来在周二公布的一项研究结果显示：与安慰剂相比，减肥药替尔泊肽(Tirzepatide)能够将肥胖或超重的成年人发展为2型糖尿病的风险降低94%。后期试验还发现，接受最高周剂量药物的成年人在176周后平均体重下降了22.9%。然而，还有一个关键问题悬而未决，患者需要服用药物多长时间？...

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The \"miracle medicine for weight loss\" almost \"prevents\" diabetes, but.....","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"LLY":1},"content_text":"不仅可以减肥，还能“预防”糖尿病，礼来减肥药势不可挡，股价隔夜涨超3%逼近历史高点，8月份以来已大涨15%。\n\n礼来在周二公布的一项研究结果显示 ：与安慰剂相比，减肥药替尔泊肽(Tirzepatide)能够将肥胖或超重的成年人发展为2型糖尿病的风险降低94%。后期试验还发现，接受最高周剂量药物的成年人在176周后平均体重下降了22.9%。\n然而，还有一个关键问题悬而未决，患者需要服用药物多长时间？\n目前医生和研究人员无法给出明确答案，但有研究表明，大多数停止服用药物的人体重会出现反弹，甚至可能恢复到比原先更重的体重。\n减肥+“预防”糖尿病\n礼来的这项研究是迄今为止对替尔泊肽进行的最长研究，涉及超过1000名成年人，持续了176周，并在随后的17周内停止治疗。这些患者普遍存在超重问题，并有糖尿病前期的迹象，即血糖水平高于正常值，增加了未来发展为2型糖尿病的风险。\n研究表明，服用Zepbound或 Mounjaro可将糖尿病风险降低94%，接受最高剂量药物治疗的患者平均减去了超过22%的体重，而接受最低剂量治疗减去了约15%体重。\n礼来公司产品开发高级副总裁Jeff Emmick博士在声明中表示，这些数据加强了长期治疗对于肥胖和糖尿病前期患者潜在的临床益处。\n结合健康饮食和增加运动，已被广泛认为是降低糖前期发展为糖尿病的有效策略。类似Zepbound和Mounjaro的GLP-1产品通过减少食物摄入量使身体感到饱腹感，减缓消化速度，并改善血糖控制。\n礼来公司首席执行官表示，服用GLP-1减肥药的人每天摄入的热量减少了800卡路里，相当于一顿饭的热量。\n值得一提的是，Tirzepatide由于作用于两种不同的激素受体（GLP-1和GIP），而不是一种，因此通常比诺和诺德的司美格鲁肽更为有效。\n一个关键问题悬而未决\n然而，一个关键问题仍然悬而未决：患者需要服用这些药物多长时间？如果患者在服用Zepbound或Mounjaro后减去了大量体重，不再有糖尿病前期或肥胖问题，他们是否可以停止服用这些药物？\n目前，医生和研究人员无法给出明确答案。研究结果显示，大多数人在停止治疗后，参与者体重有所回升，甚至可能恢复到比原先更重的体重。糖尿病症状加重，但根据第三阶段的最新结果，发展为糖尿病的风险仍然比安慰剂组低88%。\n此外，保险公司通常不会为没有可诊断健康问题的人支付每月超过1000美元的药物费用。减肥药也正进行预防和治疗其他疾病的测试，括痴呆症、肝病以及药物和酒精成瘾。目前尚不清楚保险公司将如何覆盖这些药物，以及人们是否愿意长期承受常见的副作用，如恶心和胃肠问题。风险提示及免责条款\n\n            市场有风险，投资需谨慎。本文不构成个人投资建议，也未考虑到个别用户特殊的投资目标、财务状况或需要。用户应考虑本文中的任何意见、观点或结论是否符合其特定状况。据此投资，责任自负。","kind":null,"is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"1","news_tag":"Product Release","news_rank":0,"symbols":[],"gpt_button":0},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"deviceId":"web-server-community-laohu8-v3","version":"4.26.2","shortVersion":"4.26.2","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2461785225"}