先声药业(02096.HK)：SIM0508(Polθ小分子抑制剂)获国家药品监督管理局签发药物临床试验批准通知书

格隆汇08-22 20:17

格隆汇8月22日丨先声药业(02096.HK)公告，于2024年8月22日，集团自主研发的抗肿瘤候选药物－DNA聚合酶θ(Polθ)小分子抑制剂SIM0508已获得中国国家药品监督管理局(NMPA)签发的药物临床试验批准通知书，拟开展SIM0508用于晚期实体瘤的临床试验。DNA聚合酶θ(Polθ)是一种广泛存在于动植物中的DNA修复酶，其介导的微同源末端连接(MMEJ)修复通路是DNA双链断裂...

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