礼来：替尔泊肽将肥胖成人患二型糖尿病风险降低94%，体重下降近23%

澎湃新闻08-20

礼来视觉中国资料图明星GLP-1（胰高血糖素样肽-1）药物公布积极研究结果。当地时间8月20日，美国礼来公司在官网发布消息称，旗下明星GLP-1药物替尔泊肽将患有糖尿病前期和肥胖或超重的成年人进展为二型糖尿病的风险显著降低94%。或受上述消息影响，礼来美股20日盘前一度涨超2%。上述数据来自SURMOUNT-1研究的积极顶线结果，该研究在1032名患有糖尿病前期和肥胖或超重的成人中评估替尔泊肽...

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6日举行。值得一提的是，礼来曾公布SURMOUNT-1在72周时的研究数据，显示15mg替尔泊肽治疗72周平均减重20.9%，10mg剂量组平均减重19.5%，5mg剂量组平均减重15%磅，三分之一的患者减重超过体重的四分之一。替尔泊肽是每周注射一次的GLP-1/GIP双重激动剂，最早于2022年5月在美国获批用于糖尿病治疗，2023年11月8日在美国获批用于减重。今年5月，替尔泊肽糖尿病适应证在国内获批，7月减重适应证也正式获批。财报显示，替尔泊肽降糖版Mounjaro上半年收入48.97亿美元，其中二季度收入30.91亿美元，这两个数据均是去年同期的三倍以上；减重版Zepound上半年收入17.61亿美元，其中二季度收入12.43亿美元。也就是说，替尔泊肽一款单品第二季度贡献43.34亿美元，上半年贡献66.58亿美元的收入，占上半年总营收的比重约33%。GLP-1药物原本用于二型糖尿病治疗，近两年因在减重领域的效果而在全球走红。除了礼来的替尔泊肽，诺和诺德的司美格鲁肽也曾提到延缓糖尿病前期进展的功效。诺和诺德介绍，该药的全球大型临床研究STEP系列研究共纳入约25000例超重和肥胖受试者。除了显示司美格鲁肽的减重效果，STEP系列研究结果显示，诺和盈可减少腰围、降低内脏脂肪、改善血脂、延缓糖尿病前期进展等。诺和诺德和礼来被称为“GLP-1双雄”，两家公司都在积极拓展自家GLP-1药物的适应证天花板。以心血管获益为例，当地时间7月25日，诺和诺德宣布，欧洲药品管理局(EMA)支持Wegovy用于降低没有糖尿病的超重或肥胖成年人的主要心脏病和中风风险。美国食品药品监督管理局(FDA）今年早些时候曾批准该药物用于预防肥胖人群的心血管事件。8月1日，礼来宣布SUMMIT 3期临床研究取得了积极结果，替尔泊肽降低了心力衰竭结局风险（通过复合终点评估），并改善心力衰竭症状和身体功能受限。","kind":null,"is_publish_news":true,"is_publish_highlight":false,"is_publish_live":false,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"2","news_tag":"Product Release,Business 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