Prelude Therapeutics(PRLD.US)一度暴涨28%！与默沙东(MRK.US)达成临床试验合作和供应协议

智通财经07-09

智通财经获悉，近日，Prelude Therapeutics(PRLD.US)与默沙东(MRK.US)达成临床试验合作与供应协议。根据协议条款，2期临床研究将评估Prelude Therapeutics旗下疗法PRT3789与默沙东的抗PD-1肿瘤免疫疗法KEYTRUDA联合治疗SMARCA4突变癌症患者的效果。Prelude Therapeutics和默沙东将各自保留各自疗法的所有商业权利，包括作为单一疗法或联合疗法。消息传出后，Prelude Therapeutics一度飙涨28%；截至发稿，该公司股价周二盘前回落，微跌0.2%。

根据该协议，默沙东将向Prelude Therapeutics提供Keytruda，Prelude Therapeutics将赞助一项2期临床联合试验，以评估其“PRT3789”SMARCA2降解剂与Keytruda联合用于治疗携带SMARCA4突变的患者。

PRT3789是一种高选择性、一流的SMARCA2降解剂，目前在生物标志物选择的SMARCA4突变患者中处于1期临床开发阶段。招募仍在进行中，该公司预计将在2024年中期完成单药剂量递增，并确定推荐的2期剂量。

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