百奥赛图-B(02315)全人共轻链小鼠RenLite®技术平台获美国专利及商标局专利授权

金吾财讯06-21

金吾财讯 | 百奥赛图-B(02315)公布，宣布其自主研发的全人共轻链小鼠RenLite®技术平台获得美国专利及商标局(United States Patent and TrademarkOffice)专利授权。

RenLite小鼠是百奥赛图利用自主研发的超大片段染色体工程技术-SUPCE(sizeunlimited precise chromosome engineering)制备而成，具有完整的人抗体重链可变区基因和固定的人抗体轻链可变区基因，可产生具有共同轻链的全人抗体，在双抗组装时能够有效避免轻重链错配，显着降低CMC工艺开发难度；这些抗体具有丰富的多样性，组成的双抗分子结构与单抗类似，显示出良好的理化性质。百奥赛图已基于RenLite及RenLite KO小鼠生成针对200+TAA靶点的抗体库，可快速应用于双抗及双抗ADC等药物的开发。

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