GSK(GSK.US)单抗一线疗法2期临床试验取得100%临床完全缓解率

智通财经06-04

智通财经APP获悉，6月4日，GSK(GSK.US)宣布其PD-1抑制剂Jemperli(dostarlimab)替代手术作为错配修复缺陷(dMMR)局部晚期直肠癌一线疗法2期临床试验的更新长期数据。根据新闻稿，该试验在42名完成Jemperli治疗的患者中显示出“前所未见”的100%临床完全缓解率(cCR)，前24例评估患者在中位随访26.3个月期间，观察到持续的临床完全缓解。详细数据公布于今年...

网页链接

免责声明：本文观点仅代表作者个人观点，不构成本平台的投资建议，本平台不对文章信息准确性、完整性和及时性做出任何保证，亦不对因使用或信赖文章信息引发的任何损失承担责任。

精彩评论

我们需要你的真知灼见来填补这片空白

发表看法

{"i18n":{"language":"zh_CN"},"isChannel":false,"data":{"share":"https://www.laohu8.com/m/news/2440211594?lang=zh_CN&edition=full","thumbnail":"","is_english":false,"pubTime":"2024-06-04 10:27","share_image_url":"https://static.laohu8.com/e9f99090a1c2ed51c021029395664489","id":"2440211594","market":"hk","top_or_hot":-1,"title":"GSK(GSK.US)单抗一线疗法2期临床试验取得100%临床完全缓解率","media":"智通财经","content":"<div>\n<p>智通财经APP获悉，6月4日，GSK(GSK.US)宣布其PD-1抑制剂Jemperli(dostarlimab)替代手术作为错配修复缺陷(dMMR)局部晚期直肠癌一线疗法2期临床试验的更新长期数据。根据新闻稿，该试验在42名完成Jemperli治疗的患者中显示出“前所未见”的100%临床完全缓解率(cCR)，前24例评估患者在中位随访26.3个月期间，观察到持续的临床完全缓解。详细数据公布于今年...</p>\n\n<a href=\"http://www.zhitongcaijing.com/content/detail/1130557.html\">网页链接</a>\n\n</div>\n","source":"stock_zhitongcaijing","html":"<!DOCTYPE html>\n<html>\n<head>\n<meta http-equiv=\"Content-Type\" content=\"text/html; charset=utf-8\" />\n<meta name=\"viewport\" content=\"width=device-width,initial-scale=1.0,minimum-scale=1.0,maximum-scale=1.0,user-scalable=no\"/>\n<meta name=\"format-detection\" content=\"telephone=no,email=no,address=no\" />\n<title>GSK(GSK.US)单抗一线疗法2期临床试验取得100%临床完全缓解率</title>\n<style type=\"text/css\">\na,abbr,acronym,address,applet,article,aside,audio,b,big,blockquote,body,canvas,caption,center,cite,code,dd,del,details,dfn,div,dl,dt,\nem,embed,fieldset,figcaption,figure,footer,form,h1,h2,h3,h4,h5,h6,header,hgroup,html,i,iframe,img,ins,kbd,label,legend,li,mark,menu,nav,\nobject,ol,output,p,pre,q,ruby,s,samp,section,small,span,strike,strong,sub,summary,sup,table,tbody,td,tfoot,th,thead,time,tr,tt,u,ul,var,video{ font:inherit;margin:0;padding:0;vertical-align:baseline;border:0 }\nbody{ font-size:16px; line-height:1.5; color:#999; background:transparent; }\n.wrapper{ overflow:hidden;word-break:break-all;padding:10px; }\nh1,h2{ font-weight:normal; line-height:1.35; margin-bottom:.6em; }\nh3,h4,h5,h6{ line-height:1.35; margin-bottom:1em; }\nh1{ font-size:24px; }\nh2{ font-size:20px; }\nh3{ font-size:18px; }\nh4{ font-size:16px; }\nh5{ font-size:14px; }\nh6{ font-size:12px; }\np,ul,ol,blockquote,dl,table{ margin:1.2em 0; }\nul,ol{ margin-left:2em; }\nul{ list-style:disc; }\nol{ list-style:decimal; }\nli,li p{ margin:10px 0;}\nimg{ max-width:100%;display:block;margin:0 auto 1em; }\nblockquote{ color:#B5B2B1; border-left:3px solid #aaa; padding:1em; }\nstrong,b{font-weight:bold;}\nem,i{font-style:italic;}\ntable{ width:100%;border-collapse:collapse;border-spacing:1px;margin:1em 0;font-size:.9em; }\nth,td{ padding:5px;text-align:left;border:1px solid #aaa; }\nth{ font-weight:bold;background:#5d5d5d; }\n.symbol-link{font-weight:bold;}\n/* header{ border-bottom:1px solid #494756; } */\n.title{ margin:0 0 8px;line-height:1.3;color:#ddd; }\n.meta {color:#5e5c6d;font-size:13px;margin:0 0 .5em; }\na{text-decoration:none; color:#2a4b87;}\n.meta .head { display: inline-block; overflow: hidden}\n.head .h-thumb { width: 30px; height: 30px; margin: 0; padding: 0; border-radius: 50%; float: left;}\n.head .h-content { margin: 0; padding: 0 0 0 9px; float: left;}\n.head .h-name {font-size: 13px; color: #eee; margin: 0;}\n.head .h-time {font-size: 11px; color: #7E829C; margin: 0;line-height: 11px;}\n.small {font-size: 12.5px; display: inline-block; transform: scale(0.9); -webkit-transform: scale(0.9); transform-origin: left; -webkit-transform-origin: left;}\n.smaller {font-size: 12.5px; display: inline-block; transform: scale(0.8); -webkit-transform: scale(0.8); transform-origin: left; -webkit-transform-origin: left;}\n.bt-text {font-size: 12px;margin: 1.5em 0 0 0}\n.bt-text p {margin: 0}\n</style>\n</head>\n<body>\n<div class=\"wrapper\">\n<header>\n<h2 class=\"title\">\nGSK(GSK.US)单抗一线疗法2期临床试验取得100%临床完全缓解率\n</h2>\n\n<h4 class=\"meta\">\n\n\n2024-06-04 10:27 北京时间&nbsp;&nbsp;&nbsp;<a href=http://www.zhitongcaijing.com/content/detail/1130557.html><strong>智通财经</strong></a>\n\n\n</h4>\n\n</header>\n<article>\n<div>\n<p>智通财经APP获悉，6月4日，GSK(GSK.US)宣布其PD-1抑制剂Jemperli(dostarlimab)替代手术作为错配修复缺陷(dMMR)局部晚期直肠癌一线疗法2期临床试验的更新长期数据。根据新闻稿，该试验在42名完成Jemperli治疗的患者中显示出“前所未见”的100%临床完全缓解率(cCR)，前24例评估患者在中位随访26.3个月期间，观察到持续的临床完全缓解。详细数据公布于今年...</p>\n\n<a href=\"http://www.zhitongcaijing.com/content/detail/1130557.html\">网页链接</a>\n\n</div>\n\n\n</article>\n</div>\n</body>\n</html>\n","isBrief":false,"type":0,"news_type":1,"symbol":"BK4585","symbol_name":"ETF&股票定投概念","start_time":0,"source_url":"http://www.zhitongcaijing.com/content/detail/1130557.html","article_id":"2440211594","we_media_id":null,"thumbnails":[],"rights":null,"url":"https://stock-news.laohu8.com/highlight/detail?id=2440211594","pubTimestamp":1717468021,"sourceInfo":{"source_id":"stock_zhitongcaijing","name":"智通财经网"},"weMediaInfo":null,"summary":"智通财经APP获悉，6月4日，GSK宣布其PD-1抑制剂Jemperli替代手术作为错配修复缺陷局部晚期直肠癌一线疗法2期临床试验的更新长期数据。根据新闻稿，该试验在42名完成Jemperli治疗的患者中显示出“前所未见”的100%临床完全缓解率，前24例评估患者在中位随访26.3个月期间，观察到持续的临床完全缓解。Jemperli在2021年4月获美国FDA批准，作为在先前接受过含铂疗法后的dMMR晚期或复发性子宫内膜癌的单药治疗。","collect":0,"end_time":0,"defaultTopTitle":"zhitongcaijing.com","property":[],"viewcount":null,"language":"zh","relate_stocks":{"BK4585":"ETF&股票定投概念","BK1141":"生命科学工具和服务","BK1576":"医药外包概念","03347":"泰格医药","BK4588":"碎股","GSK.UK":"葛兰素史克","BK4007":"制药","BK1583":"高瓴概念","BK4532":"文艺复兴科技持仓","GSK":"葛兰素史克","LU1829250122.USD":"高盛欧洲核心股票组合Acc"},"translate_title":"100% clinical complete response rate in Phase 2 clinical trial of GSK (GSK.US) mAb first-line therapy","themeId":null,"isJumpTheme":false,"ttsUrl":null,"symbols_score_info":{"03347":1,"GSK":1,"GSK.UK":0.6},"content_text":"智通财经APP获悉，6月4日，GSK(GSK.US)宣布其PD-1抑制剂Jemperli(dostarlimab)替代手术作为错配修复缺陷(dMMR)局部晚期直肠癌一线疗法2期临床试验的更新长期数据。根据新闻稿，该试验在42名完成Jemperli治疗的患者中显示出“前所未见”的100%临床完全缓解率(cCR)，前24例评估患者在中位随访26.3个月期间，观察到持续的临床完全缓解。详细数据公布于今年美国临床肿瘤学会(ASCO)年会上。Jemperli用于治疗dMMR/微卫星高度不稳定(MSI-H)直肠和结直肠癌(CRC)的其他注册试验正在招募患者中。据了解，Jemperli是一种能够与PD-1受体结合，并阻断其与配体PD-L1和PD-L2交互作用的抗体。Jemperli在2021年4月获美国FDA批准，作为在先前接受过含铂疗法后的dMMR晚期或复发性子宫内膜癌的单药治疗。该疗法并在2023年7月获批与卡铂和紫杉醇联合用药，并接续Jemperli作为单药以治疗由美国FDA批准的检测方法确定为dMMR或MSI-H的原发性晚期或复发性子宫内膜癌成人患者。此外，Jemperli在2021年8月获FDA加速批准用于治疗携带dMMR的复发或晚期实体瘤患者，这些患者的dMMR特征由FDA批准的检测确认，在接受前期治疗后疾病继续进展，并且没有其它满意的替代治疗选择。","kind":null,"is_publish_news":true,"is_publish_highlight":false,"is_publish_live":null,"is_publish_wemedia":null,"editions":null,"column":"","sentiment":"0","news_tag":"","news_rank":0,"symbols":[],"gpt_button":1},"commentList":[],"isCommentEnd":true,"newsSizeData":{"likeSize":0,"commentSize":0,"repostSize":0,"favoriteSize":0,"likeStatus":false,"favoriteStatus":false},"APP":{"userAgent":"Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)","isDev":false,"isTTM":false,"deviceId":"web-server-community-laohu8-v3","version":"4.25.1","shortVersion":"4.25.1","platform":"web","vendor":"web","appName":"laohu8","isIOS":false,"isAndroid":false,"isTiger":false,"isTHS":false,"isWeiXin":false,"isWeiXinMini":false,"isWeiBo":false,"isQQ":false,"isBaiduSwan":false,"isBaiduBox":false,"isDingTalk":false,"isToutiao":false,"isOnePlus":false,"isHuaWei":false,"isXiaomi":false,"isXiaomiWebView":false,"isOppo":false,"isVivo":false,"isSamsung":false,"isMobile":false},"href":"/m/news/2440211594"}